Abstract
Bacteria have been used for more than a century to treat solid tumors. Because solid tumors generate an anaerobic environment, we evaluated the anti-tumor effect of the obligate anaerobe strain KK378, derived from Lactobacillus casei (L. casei), using mice bearing head and neck cancer. Wild-type L. casei is a nonpathogenic bacterium that is commonly used in foods. Moreover, patients with head and neck squamous cell carcinoma often have multiple cancers and cervical lymph node metastasis that can be directly sensed beneath the skin. To establish the animal model bearing head and neck cancer, we inoculated each of human squamous cell carcinoma cell lines, SAS, HSQ89, and HSC2, on the back skin of BALB/cSlc-nu/nu mice. After tumor formation, L. casei KK378 was administered directly into the tumor, and tumor size and serum cytokine levels were analyzed. Mice injected with 108 cfu of L. casei KK378 showed reduction in tumor growth compared with PBS control; especially, the SAS tumor was significantly reduced (p = 0.008). Administered L. casei KK378 was detected in tumor tissues but not in normal tissues (liver, kidney, and lung) of SAS tumor-bearing mice, which was associated with increased blood cytokines (TNF-α, IFN-γ, IL-5, IL-10...Continue Reading
References
Aug 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·F MomoseS Sasaki
Sep 1, 1986·The Journal of Urology·M AsanoT Takayama
Jan 1, 1988·Cancer Immunology, Immunotherapy : CII·T MatsuzakiM Mutai
Jan 1, 1988·Cancer Immunology, Immunotherapy : CII·I KatoM Mutai
Jan 1, 1988·Medical Microbiology and Immunology·T MatsuzakiM Mutai
Jan 1, 1996·Thorax·G V Gill, A Holden
Nov 24, 1998·Infection and Immunity·M MiettinenI Julkunen
Apr 25, 2000·Medical Microbiology and Immunology·A TakagiT Yokokura
Jul 5, 2001·Breast Cancer Research and Treatment·K YazawaS Taniguchi
May 24, 1952·British Medical Journal·F O GRAHAM, P N COLEMAN
Dec 16, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J P CannonL H Danziger
Sep 9, 2006·Clinical and Vaccine Immunology : CVI·Kan ShidaMasanobu Nanno
Sep 1, 1891·Annals of Surgery·W B Coley
Nov 1, 1947·Proceedings of the Society for Experimental Biology and Medicine·R C PARKER, H C PLUMMER
Jun 29, 2010·Cancer Science·Shun'ichiro TaniguchiJun Amano
May 17, 2012·Cancer Science·Xiang-Bo WanQuentin Liu
Jul 22, 2014·Journal of Pharmaceutical Sciences·Jun FangHiroshi Maeda
Nov 7, 2015·Science·Ayelet SivanThomas F Gajewski
Nov 26, 2015·Journal of Medicinal Food·Hyun Ah LeeKun-Young Park
Nov 4, 2017·Science·V GopalakrishnanJ A Wargo
Nov 4, 2017·Science·Bertrand RoutyLaurence Zitvogel
Citations
Apr 30, 2020·BMC Complementary Medicine and Therapies·Nariman K Badr El-DinMamdooh Ghoneum
Dec 22, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Aja BadgeleyAshakumary Lakshmikuttyamma
Jan 17, 2021·International Journal of Molecular Sciences·Vincent Q SierMunitta Muthana