Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice

PPAR Research
Sorim ChoungBon Jeong Ku

Abstract

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activators, thiazolidinediones, (TZDs), are insulin sensitizers used as a treatment for NAFLD. However, TZDs are a controversial treatment for NAFLD because of conflicting results regarding hepatic steatosis and fibrosis. To evaluate a possible effective drug for treatment of NAFLD, we investigated the effects of a newly developed TZD, lobeglitazone, with an emphasis on hepatic lipid metabolism. Lobeglitazone treatment for 4 weeks in high fat diet- (HFD-) induced obese mice (HL group) improved insulin resistance and glucose intolerance compared to HFD-induced obese mice (HU group). The gene levels related to hepatic gluconeogenesis also decreased after treatment by lobeglitazone. The livers of mice in the HL group showed histologically reduced lipid accumulation, with lowered total plasma cholesterol and triglyceride levels. In addition, the HL group significantly decreased the hepatic expression of genes associated with lipid synthesis, cholesterol biosynthesis, and lipid droplet development and increased the hepatic expression of genes associated with fatty acid β-oxidation, thus sugge...Continue Reading

References

Feb 13, 2001·American Journal of Physiology. Endocrinology and Metabolism·A MinnichG Bilder
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Farrell, Claire Z Larter
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Jun 4, 2008·Annual Review of Biochemistry·Peter Tontonoz, Bruce M Spiegelman
Oct 18, 2008·Immunobiology·Attila Szanto, Laszlo Nagy
Apr 30, 2010·The New England Journal of Medicine·Arun J SanyalUNKNOWN NASH CRN
Jul 24, 2010·Nature·Jang Hyun ChoiBruce M Spiegelman
Dec 2, 2010·Nature Reviews. Gastroenterology & Hepatology·Lionel Hebbard, Jacob George
May 11, 2011·Nature Reviews. Endocrinology·Briohny W Smith, Leon A Adams
Jun 28, 2011·Science·Jonathan C CohenHelen H Hobbs
Aug 21, 2013·Nature Reviews. Gastroenterology & Hepatology·Alexander WreeAriel E Feldstein
Apr 29, 2015·Journal of Hepatology·Vlad RatziuArun Sanyal
Sep 13, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G KimB-S Cha

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Citations

Feb 6, 2020·Current Vascular Pharmacology·Michael DoumasVasilios G Athyros
Feb 13, 2020·Biomedicines·Yvonne Oligschlaeger, Ronit Shiri-Sverdlov
Jun 17, 2020·Expert Opinion on Pharmacotherapy·Joeri LambrechtFrank Tacke
Apr 18, 2019·Diabetes & Metabolism Journal·Kyung Soo KimCheol Young Park
Aug 14, 2020·Clinical and Molecular Hepatology·Kyung-Soo Kim, Byung-Wan Lee
Oct 26, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kyung-Soo KimCheol-Young Park
Apr 20, 2021·Diabetes & Metabolism Journal·Jaehyun BaeBong-Soo Cha

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Methods Mentioned

BETA
light microscopy
ELISA
PCR

Software Mentioned

ImageJ
Graph Prism
Rotor
[UNK] 6000 rotary

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