Treatment with melatonin induces a reduction of Toxoplasma gondii development in LLC-MK2 cells

Parasitology Research
Nayara Inocencio MachadoSergio Henrique Seabra

Abstract

It is known that the current treatment for toxoplasmosis causes side effects. Thus, it is essential to develop new therapies with reduced adverse effects while concurrently maintaining broad coverage and prophylactic therapy. Melatonin is a hormone that participates in the circadian cycle in vertebrates and has antioxidant, immunomodulatory, and antitumoral functions. In addition, it has been shown that melatonin can modulate immune responses and parasitic development during infection by Trypanosoma cruzi and Leishmania spp. Furthermore, studies indicate that melatonin increases the number of lymphocytes in rats infected by Toxoplasma gondii. However, there is no information on the possible effects of melatonin in T. gondii-infected host cells in vitro. This study analyzed the effects of melatonin treatment in the monkey kidney cell epithelial cell line, LLC-MK2, after infection with T. gondii. LLC-MK2 cells were infected and treated/not treated with melatonin, and the infection index was then quantified. Melatonin treatment did not alter host cell viability and was able to reduce parasite proliferation in LLC-MK2 cells at 24 and 48 h and at 6 days. Analysis by scanning electron microscopy confirmed reduction of parasite prolif...Continue Reading

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Citations

Jan 28, 2021·Pharmaceutics·Dalia M Kopustinskiene, Jurga Bernatoniene
Jun 3, 2021·International Journal of Molecular Sciences·Karolina Szewczyk-GolecCelestyna Mila-Kierzenkowska
Jun 30, 2021·Parasitology Research·Seyed Hossein AbdollahiSoudeh Khanamani Falahati-Pour

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Methods Mentioned

BETA
scanning electron microscopy
Light microscopy
transmission electron microscopy
confocal microscopy

Software Mentioned

GraphPad Prism

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