Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus

Drug Design, Development and Therapy
Yujuan FanJialin Yang

Abstract

The objective of this study was to assess the effects of metformin monotherapy or combined treatment with a dipeptidyl peptidase-4 inhibitor (vildagliptin) on apelin levels in patients with type 2 diabetes mellitus. Twenty-five patients with poor glycemic control (glycosylated hemoglobin >6.5% [48 mmol/mol]) taking 1,000 mg of metformin daily and 25 healthy controls matched for age and body mass index were enrolled in this study. Anthropometric parameters, glycemic and lipid profile, insulin resistance (homeostasis model assessment of insulin resistance index), and apelin levels were measured at baseline and at 12-week and 24-week visits. At baseline, apelin levels were higher in the T2DM patients than in the controls (1.93±1.81 ng/mL versus 6.09±4.90 ng/mL; P<0.05). After 12 weeks, when vildagliptin was added, fasting blood glucose and glycosylated hemoglobin decreased, and apelin levels increased further (from 6.09±4.90 ng/mL to 24.23±12.59 ng/mL; P<0.05). Follow-up at 24 weeks showed no further improvement in the glycemic profile and no further increase in apelin levels. Both metformin and vildagliptin favorably changed glycemic indices and apelin levels. For patients inadequately controlled on a low dose of metformin, addit...Continue Reading

Citations

Apr 17, 2016·Diabetes & Metabolic Syndrome·Akar KarakoçEda Dokumacioglu
Dec 21, 2018·Expert Opinion on Therapeutic Targets·Isabelle Castan-LaurellPhilippe Valet
Nov 11, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hui ZhengJialin Yang
Dec 7, 2017·Current Medicinal Chemistry·Marta Olivera-Santa CatalinaJose J Lopez
Apr 11, 2021·Molecular and Cellular Endocrinology·I Castan-LaurellP Valet
May 27, 2021·Analytical Methods : Advancing Methods and Applications·Jing ZhangLi-Wei Zou
Jul 18, 2017·Diabetes & Metabolic Syndrome·Farzaneh Ghafarian AlipourNosratollah Zarghami

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Statistical Package for the Social Sciences

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