Treatment with nitric oxide donors diminishes hyperinfection by Strongyloides venezuelensis in mice treated with dexamethasone

Acta Tropica
A L RuanoAntonio Muro

Abstract

The effects of using nitric oxide (NO) donors and inhibitors in experimental strongyloidiasis were showed using, both naïve and dexamethasone immunosuppressed BALB/c mice infected with Strongyloides venezuelensis. Aminoguanidine, an inhibitor of inducible NO synthase and LA419 a NO donor, were administered. Dexamethasone was used to induce immunosuppression. The study in BALB/c mice revealed increases in counts of fecal eggs, larvae in lungs and parasitic females following treatment with aminoguanidine, while mice treated with LA419 had limited egg output with low larval and adult recoveries. Mice immunosuppressed with dexamethasone developed hyperinfection with high long lasting fecal egg emission, high numbers of larvae in lungs and high numbers of parasitic females in the intestine even when the infection had already been cleared in non-immunosuppressed infected controls. Mice treated with dexamethasone and aminoguanidine had the highest egg output and the highest larva and parasitic female recovery showing a severe hyperinfection syndrome. In contrast, treatment with dexamenthasone and LA419 resulted in a controlled hyperinfection syndrome and these mice were able to eliminate the parasite. Therefore, NO modulation appears ...Continue Reading

References

Jan 17, 2004·Clinical Microbiology Reviews·Paul B Keiser, Thomas B Nutman
Nov 16, 2007·Muscle & Nerve·Jenna L BettersDavid S Criswell
Mar 7, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Luis A MarcosEduardo Gotuzzo
Nov 7, 2009·Parasitology International·Nnaemeka C IriemenamAdetayo F Fagbenro-Beyioku
Feb 20, 2010·Journal of Biomedicine & Biotechnology·Antonio Muro, José-Luís Pérez-Arellano
Feb 23, 2010·Journal of the American Academy of Dermatology·Amy BasileNoah Craft
Aug 25, 2010·Current Opinion in Infectious Diseases·Martin MontesNicolas Barros
Jun 3, 2011·The American Journal of Tropical Medicine and Hygiene·Eleuza R MachadoLúcia H Faccioli
Mar 6, 2012·Primates; Journal of Primatology·Alan Lane de MeloWanderlany Amâncio Martins
May 16, 2013·PLoS Neglected Tropical Diseases·Zeno BisoffiMarco Albonico
Jul 23, 2013·PLoS Neglected Tropical Diseases·Fabian SchärPeter Odermatt
Mar 29, 2014·Frontiers in Immunology·Koubun YasudaKenji Nakanishi

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Citations

Feb 26, 2016·Parasitology·Minka Breloer, David Abraham
May 11, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Natália Yoshie KawakamiWander Rogério Pavanelli
Jul 24, 2018·Parasite Immunology·Rosângela Maria RodriguesJulia Maria Costa-Cruz
Jul 6, 2017·Frontiers in Cellular and Infection Microbiology·Cristin N BockSebastian Rausch

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