Treatment with omega-3 fatty acids but not exendin-4 improves hepatic steatosis

European Journal of Gastroenterology & Hepatology
Deepti G BulchandaniLaura M Alba

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the Western world. The aim of this study was to evaluate the biochemical and histological effects of omega-3 fatty acid and exendin-4 treatment on NAFLD in an animal model. Sixty-three 8-week-old outbred Sprague-Dawley male rats were used for this study. Three animals were used as procedure controls, and 30 rats were fed a methionine and choline deficient (MCD) diet and 30 were fed a regular chow diet. In each group of 30 animals, 10 served as controls, 10 received exendin-4, and 10 received omega-3 fatty acids. After 75 days of treatment, the animals were euthanized, the tissues and serum were harvested, and the livers were formalin-fixed for histology. The MCD diet was exceptionally efficient at producing fatty livers. The MCD control animals had a liver steatosis score of 38+/-6.7 (of 50 possible); treatment with exendin-4 was not associated with a significant reduction of steatosis (44+/-5.16, P=0.07) and the omega-3 fatty acid treatment was associated with a significant decrease in the liver steatosis score (15.6+/-13.46, P<0.001) compared with both the controls and the exendin-4 groups. The omega-3 fatty acid treatment increased s...Continue Reading

References

May 1, 1997·The American Journal of Clinical Nutrition·W S Harris
Apr 18, 1998·Gastroenterology·C P Day, O F James
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Jan 5, 2000·The American Journal of Clinical Nutrition·J Eritsland
Apr 20, 2000·The Journal of Clinical Investigation·I A LeclercqG R Robertson
Mar 10, 2001·The American Journal of Gastroenterology·A J Sanyal
Apr 12, 2001·Seminars in Liver Disease·E M Brunt
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Josephine M EganDariush Elahi
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniDavid W Crabb
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Motohiro SekiyaHitoshi Shimano
Aug 28, 2004·Clinics in Liver Disease·Amin A Nanji
Aug 23, 2005·Lancet·Karsten H Weylandt, Jing X Kang
Sep 15, 2005·Current Opinion in Pediatrics·Anna Wieckowska, Ariel E Feldstein
Oct 6, 2005·The International Journal of Biochemistry & Cell Biology·Diva D De LeónDoris A Stoffers
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaokun DingFrank A Anania
Jan 31, 2006·Diabetes Care·Paul S Denker, Paul E Dimarco
Jul 13, 2006·Current Opinion in Lipidology·William S Harris, Deepti Bulchandani
Sep 7, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Maarten E TushuizenRobert J Heine
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christoph SchmöckerJing X Kang
Sep 18, 2007·Journal of Hepatology·Ashraf Mohammad El-BadryPierre-Alain Clavien
Jan 8, 2008·World Journal of Gastroenterology : WJG·Eric R KallwitzScott J Cotler
Jan 8, 2008·The American Journal of Gastroenterology·Christine Carter-KentAriel E Feldstein
Apr 28, 2009·Current Opinion in Gastroenterology·Onpan Cheung, Arun J Sanyal

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Citations

Oct 24, 2013·Nutrition Reviews·Dimitrios G BouzianasApostolos I Hatzitolios
Aug 3, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Gunveen KaurNicky Konstantopoulos
Aug 19, 2015·The Proceedings of the Nutrition Society·Donald B JumpKelli A Lytle
May 13, 2011·Current Opinion in Lipidology

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