Abstract
Background Some studies have linked the use of paracetamol (PAR) with adverse effects like wheezing, exacerbation of asthma symptoms and other respiratory problems. Other studies are inconclusive or deny this correlation. This makes the association between PAR and airway hypersensitivity very controversial and still under debate. Objective This work investigated if chronic treatment with PAR in rats could directly affect the contraction and relaxation for different stimulus in isolated airways. Methods Rats were treated by 2 weeks with PAR (400 mg/Kg, v.o.). The blood was collected to biochemical analysis (alanine aminotransferase (ALT), aspartate aminotransferase (AST), TBARs reaction and glutathione) and isolated tracheal rings were prepared in organ bath to measuring isometric tone after contractile and relaxant stimulus. Results Hepatic enzymes (ALT, AST) and lipid peroxidation were increased after PAR-treatment, while glutathione was decreased. Rats do not present any alteration in airway myocytes responsiveness, either to contractile or relaxant stimulus (i.e. cholinergic agonist, membrane depolarization, Ca2+ influx across sarcolemma, internal Ca2+ release from sarcoplasmic reticulum, Ca2+ channel blocking, β-agonist and...Continue Reading
References
Nov 19, 1986·European Journal of Pharmacology·M Ilhan, I Sahin
Mar 1, 1983·Drugs·L F Prescott
Oct 1, 1995·Journal of Applied Physiology·C M De CastroM Bachelet
Jan 16, 2002·JAMA : the Journal of the American Medical Association·David W KaufmanAllen A Mitchell
Feb 5, 2002·Pediatrics·Samuel M LeskoAllen A Mitchell
Aug 13, 2003·Journal of Clinical Pharmacy and Therapeutics·S L NuttallM J Kendall
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ayman M Gamal el-dinMahmoud N Nagi
Mar 26, 2004·Biophysical Journal·Etienne Roux, Marko Marhl
Mar 1, 2005·American Journal of Respiratory and Critical Care Medicine·Tricia M McKeeverPatricia A Cassano
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Mar 21, 2008·The European Respiratory Journal·T TazzeoL J Janssen
Aug 2, 2008·Biological & Pharmaceutical Bulletin·Yan-Ling WuJi-Xing Nan
Aug 5, 2009·Pediatrics·Louis VernacchioAllen A Mitchell
Dec 17, 2009·The Journal of Nursing Administration·Chandra Stroth
Aug 17, 2010·American Journal of Respiratory and Critical Care Medicine·Richard W BeasleyUNKNOWN ISAAC Phase Three Study Group
Nov 1, 2011·Annals of the Rheumatic Diseases·Burkhard Hinz, Kay Brune
Jan 22, 2013·Age and Ageing·Aza AbdullaPatricia Schofield
Dec 11, 2013·Current Opinion in Allergy and Clinical Immunology·Haejin Kim, Christine C Johnson
Dec 18, 2013·The European Respiratory Journal·Kian Fan ChungW Gerald Teague
Apr 1, 2014·Expert Review of Clinical Pharmacology·Marissa BliedenRami Ben-Joseph
Jun 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer DanielssonCharles W Emala
Sep 16, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WeatherallR Beasley
May 29, 2015·British Journal of Clinical Pharmacology·Sinem Ezgi GulmezNicholas Moore
Jun 17, 2015·Chemico-biological Interactions·Zhiyong ZhengLili Ji
Nov 13, 2015·The Journal of Toxicological Sciences·Isao IshiiYoshito Kumagai
Dec 15, 2015·Clinical and Experimental Pharmacology & Physiology·Patrícia Ferreira da Silva CastroMatheus Lavorenti Rocha
Dec 18, 2015·Pharmacoepidemiology and Drug Safety·Xiaoqin LiuJiong Li
Aug 18, 2016·The New England Journal of Medicine·William J SheehanUNKNOWN NIH/NHLBI AsthmaNet
Aug 31, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Tamara Lourido-CebreiroFrancisco-Javier Gonzalez-Barcala