Treatment with poly I.C. enhances lipid peroxidation and the activity of xanthine oxidase, and decreases hepatic P-450 content and activities in mice and rats

Biochemical and Biophysical Research Communications
A KoizumiT Imamura

Abstract

Treatment of mice and rats with polyriboinosinic acid-polyribocytidylic acid (poly I.C., 5 mg/kg i.p.), a potent interferon inducer, decreased hepatic cytochrome P-450 system content and activities without influencing P-450-independent xenobiotic metabolizing enzymes. Treatment with poly I.C. decreased the content of P-450 by 28% in mice (P less than 0.05) and 30% in rats (P less than 0.05) but did not alter the activity of cytochrome c reductase. With treatment of poly I.C., the activity of XO increased 87% in mice (P less than 0.01) and 30% in rats (P less than 0.01). Lipid peroxidation was enhanced by 82% in mice (P less than 0.01) and 95% in rats (P less than 0.05). These results raise the possibility that a part of the depression of P-450 system content and activities by poly I.C. might be caused by enhanced lipid peroxidation associated with increased activity of XO.

References

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Mar 10, 1971·Biochimica Et Biophysica Acta·E OeschJ Daly
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Citations

Jan 1, 1987·Pharmacology & Therapeutics·G C Farrell
Jan 1, 1988·Pharmacology & Therapeutics·S GarattiniM D'Incalci
Jan 1, 1988·Experimental Gerontology·R J Shmookler Reis
Jan 1, 1988·Free Radical Biology & Medicine·J D Gower
Jan 9, 1998·Drug Metabolism Reviews·E T Morgan

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