Treatment with prolonged-release oxycodone/naloxone improves pain relief and opioid-induced constipation compared with prolonged-release oxycodone in patients with chronic severe pain and laxative-refractory constipation

Clinical Therapeutics
Jan PoelaertYvonne J B van Megen

Abstract

Laxative-refractory opioid-induced constipation (OIC) is defined as OIC despite using 2 laxatives with a different mechanism of action (based on the Anatomical Therapeutic Chemical Classification System level 4 term [contact laxatives, osmotically acting laxatives, softeners/emollients, enemas, and others]). OIC has a significant impact on the treatment and quality of life of patients with severe chronic pain. This noninterventional, observational, real-life study in Belgium investigated the efficacy of prolonged-release oxycodone/naloxone combination (PR OXN) treatment regarding pain relief and OIC compared with previous prolonged-release oxycodone (PR OXY) treatment for laxative-refractory OIC in daily clinical practice. Laxative-refractory OIC patients with severe chronic pain were treated with PR OXN for 12 weeks (3 visits). Pain relief (assessed on a numerical rating scale) and OIC (assessed by using the Bowel Function Index [BFI]) were evaluated at each visit. A responder was defined as a patient who had: (1) no worsening of pain at the last visit compared with visit 1 or a numerical rating scale ≤4 at visit 3/last visit; and (2) a reduction in BFI ≥12 units at visit 3/last visit compared with visit 1; or (3) a BFI ≤28.8 ...Continue Reading

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Citations

Jun 26, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anselm WongShaun L Greene
Mar 16, 2016·Therapeutic Advances in Chronic Disease·Alfred D Nelson, Michael Camilleri
May 23, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael CamilleriDavid A Katzka
Sep 26, 2017·Pain Practice : the Official Journal of World Institute of Pain·Bart J MorlionTony O'Brien
Jun 6, 2018·The Cochrane Database of Systematic Reviews·Bridget CandyPatrick Stone
Dec 26, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Paula MosińskaJakub Fichna
Jan 7, 2020·Journal of Palliative Medicine·Katherine ClarkDavid C Currow

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