Treatment with recombinant human growth hormone in short children with nephropathic cystinosis: no evidence for increased deterioration rate of renal function. The European Study Group on Growth Hormone Treatment in Short Children with Nephropathic Cystinosis

Pediatric Research
E WühlO Mehls

Abstract

To evaluate the effect of long-term treatment with recombinant human GH (rhGH) on renal function in short children with nephropathic cystinosis with and without concomitant cysteamine treatment, 36 growth-retarded children with nephropathic cystinosis (age 7.3+/-2.7 y; creatinine clearance [C(CR)] 50+/-27 mL (min x 1.73 m2)(-1) were treated with 1 IU rhGH/kg/wk for up to 5 y. The rise in serum creatinine before and during rhGH treatment was compared with that in a historical control group of cystinotic patients. The effect of concomitant cysteamine treatment on the evolution of renal function before and after the start of rhGH was evaluated separately in patients without (group A) and with cysteamine treatment (group B). The decline of C(CR) was also compared with that in noncystinotic patients with chronic renal failure with and without rhGH treatment. At study entry, serum creatinine values in group A were similar to those in the historical controls, whereas group B had significantly lower serum creatinine values. Treatment with rhGH did not accelerate the rise in creatinine independently of cysteamine treatment. There were no significant differences in the mean decline of C(CR) per year in cystinotic compared with noncystino...Continue Reading

References

Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E RitzO Mehls
Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R WankeG Brem
Mar 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W A GahlG F Reed
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M BroyerM C Gubler
Apr 16, 1987·The New England Journal of Medicine·W A GahlJ A Schneider
Jan 1, 1995·Journal of Inherited Metabolic Disease·J A SchneiderK A Berry
Aug 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F Manz, N Gretz
Aug 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N M Gretz
Feb 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I BlazyC Sachs
Mar 1, 1993·European Journal of Pediatrics·L WinklerJ Brodehl
Apr 22, 1993·The New England Journal of Medicine·T C MarkelloW A Gahl
Dec 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W G van't Hoff, N Gretz

❮ Previous
Next ❯

Citations

Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·O Mehls, S Haas
Jul 12, 2002·The New England Journal of Medicine·William A GahlJerry A Schneider
Aug 29, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco EmmaElena Levtchenko
Aug 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martijn J WilmerElena N Levtchenko
Jul 23, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Otto MehlsUNKNOWN ESCAPE Trial Group
Mar 7, 2013·The Journal of Pediatrics·Lisa Viltz, Doris A Trauner
Jan 6, 2012·Arquivos brasileiros de endocrinologia e metabologia·Flavio Moutinho Souza, Paulo Ferrez Collett-Solberg
Mar 28, 2017·The Journal of Pediatrics·Elena Levtchenko
Jul 12, 2017·Current Medical Research and Opinion·Goran MedicMichiel Hemels
May 17, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Niels Thomas HertelFritz Bangsgaard Pedersen
Jul 16, 2008·Acta Paediatrica·O MehlsD Haffner
Dec 29, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Cristina Julia Blázquez GómezFernando Santos Rodríguez
Jun 8, 2001·The Journal of Pediatrics·E WühlUNKNOWN European Study Group on Growth Hormone Treatment in Children with Nephropathic Cystinosis
Jun 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter HaffnerMaren Leifheit-Nestler
Jun 26, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Cristina Julia Blázquez GómezFernando Santos Rodríguez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
W A GahlJ A Schneider
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M BroyerMarie-Claire Gubler
© 2022 Meta ULC. All rights reserved