PMID: 9433384Jan 20, 1998Paper

Treatment with rhG-CSF for osteomyelitis in a patient with p47-phox-deficient chronic granulomatous disease

Annals of Hematology
H IsotaniY Kobayashi

Abstract

A 24-year-old woman with osteomyelitis was diagnosed as having p47-phox-deficient chronic granulomatous disease (CGD). The patient showed a marked deficiency of p47-phox, which is very rare in Japan. As the clinical response to various antibiotics including sulfamethoxazole-trimethoprim was not satisfactory, we added recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the treatment protocol. We report the beneficial clinical course of the patient, together with the effect of rhG-CSF on the granulocyte function, and the present report indicates that rhG-CSF is useful for the treatment of antibiotic-resistant infection in the variant type of p47-phox-defective CGD.

Citations

Jun 1, 2011·Clinical and Molecular Allergy : CMA·Eunkyung SongGuha Krishnaswamy
Jan 16, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Michael I PearcePaul R J Ames
Oct 26, 1999·Pediatrics International : Official Journal of the Japan Pediatric Society·M Hasui

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