Treatment with the competitive NMDA antagonist GPI 3000 does not improve outcome after cardiac arrest in dogs

Stroke; a Journal of Cerebral Circulation
M A HelfaerR J Traystman

Abstract

We previously showed that treatment with a competitive N-methyl-D-aspartate (NMDA) receptor antagonist GPI-3000 (GPI) improved short-term physiological recovery after incomplete global cerebral ischemia complicated by dense acidosis. We tested the hypothesis that GPI administered after resuscitation from cardiac arrest would improve a more long-term recovery as measured by neurobehavioral assessment and neuropathology 4 days after resuscitation. Anesthetized dogs were subjected to 7 minutes of cardiac arrest followed by vest cardiopulmonary resuscitation. Neurobehavioral outcomes were scored daily on a score ranging from 0 (normal) to 500 (worst). On the fourth day, the animals were killed, and neuropathology was evaluated in a blinded manner in the hippocampus and the neocortex by hematoxylin and eosin staining and by determination of percentage of injured neurons. Three groups of animals were treated in a randomized, blinded protocol with either saline (SAL), low-dose GPI (5 mg/kg followed by 1 mg/kg per hour for 2 hours), or high-dose GPI (25 mg/kg, followed by 5 mg/kg per hour for 2 hours). The mortality rate was higher in animals receiving GPI than in saline-treated control animals (4 of 15 deaths in SAL, 6 of 15 in the lo...Continue Reading

References

Dec 6, 1991·Science·J W OlneyM A Sesma
Oct 1, 1990·Trends in Pharmacological Sciences·J WillettsJ D Leander
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W L LanierJ D Michenfelder
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J H Swan, B S Meldrum
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BullockJ McCulloch
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y LeonovS W Stezoski
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J H SwanB S Meldrum
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H HagbergA Hamberger
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S A RousselD G Gadian
Jul 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D SauerP R Allegrini
Sep 17, 1993·Brain Research·K J AndersonT Wieloch
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsumotoR Newcomb
Jan 1, 1996·Journal of Neural Transmission·B H White, M W Vogel

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Citations

Sep 16, 2000·Journal of Pain and Symptom Management·G BennettS J Hassenbusch
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Apr 3, 2018·Cardiology in Review·Mohammad Roostan, William H Frishman
Mar 17, 2000·Neurosurgery·G R SutherlandD J McCarthy

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