Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
J SvenssonB A Bengtsson

Abstract

The effect of 2 months of treatment with the oral growth hormone (GH) secretagogue MK-677 on markers of bone metabolism was determined in healthy obese male subjects. This was a randomized, double-blind, parallel, placebo-controlled study. Twenty-four healthy obese males, 19-49 years of age, with body mass index > 30 kg/m2 were treated with MK-677 (25 mg/day; n = 12) or placebo (n = 12) for 8 weeks. MK-677 increased markers of bone formation; a 23% increase in the carboxy-terminal propeptide of type I procollagen levels and a 28% increase in procollagen III peptide levels were seen with as little as 2 weeks of MK-677 treatment (p < 0.01 and p = 0.001 vs. placebo, respectively) while a 15% increase in serum levels of osteocalcin was not detected until 8 weeks of treatment (p < 0.01 vs. placebo). Markers of bone resorption were induced within 2 weeks of treatment with MK-677; serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen were increased 26% at 8 weeks (p = 0.001 vs. placebo), and urine hydroxyproline/creatinine and calcium/creatinine ratios at 8 weeks were increased by 23% (p < 0.05 vs. placebo) and 46% (p < 0.05 vs placebo), respectively, MK-677 increased serum insulin-like growth factor binding...Continue Reading

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Citations

Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G JohannssonB A Bengtsson
Aug 3, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J Svensson
Jan 5, 2006·American Journal of Physiology. Endocrinology and Metabolism·Thomas MünzerMarc R Blackman
Apr 6, 2006·Journal of Receptor and Signal Transduction Research·Thue W Schwartz, Birgitte Holst
Jul 26, 2000·Current Opinion in Rheumatology·C OhlssonO Isaksson
Jun 8, 2004·Endocrine Reviews·Aart J van der LelyEzio Ghigo
Nov 20, 2018·Yonsei Medical Journal·Junghun LeeHo Seong Kim
Jan 29, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J SvenssonB-A Bengtsson

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