Treatments for Crohn's Disease-Associated Bowel Damage: A Systematic Review

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Benjamin ParienteEdouard Louis

Abstract

Despite significant advances in the treatment of Crohn's disease (CD), most patients still develop stricturing or penetrating complications that require surgical resections. We performed a systematic review of mechanisms and potential treatments for tissue damage lesions in CD patients. We searched the PubMed, MBASE, and Cochrane databases from January 1960 to July 2017 for full-length articles on CD, fibrosis, damage lesions, mesenchymal stem cells, and/or treatment. We also searched published conference abstracts and performed manual searches of all reference lists of relevant articles. Mechanisms of intestinal damage in patients with CD include fibroblast proliferation and migration, activation of stellate cells, recruitment of intestinal or extra-intestinal fibroblast, and cell trans-differentiation. An altered balance of metalloproteinases and tissue inhibitors of metalloproteinases might contribute to fistula formation. Treatment approaches that reduce excessive transforming growth factor beta (TGFB) activation might be effective in treating established intestinal damage. Stem cell therapies have been effective in tissue damage lesions in CD. Particularly, randomized controlled trials have shown local injections of mesenc...Continue Reading

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Citations

Apr 9, 2020·Intestinal research·Jun Hwan YooFlorian Rieder
Apr 22, 2020·Expert Review of Gastroenterology & Hepatology·Salvatore CucchiaraLaura Stronati
Sep 10, 2020·Frontiers in Immunology·L CleenewerkAstrid Hogenkamp
Mar 28, 2020·United European Gastroenterology Journal·Sara El OualiFlorian Rieder
Aug 22, 2020·World Journal of Gastroenterology : WJG·Friederike CordesDominik Bettenworth
Jul 24, 2021·Alimentary Pharmacology & Therapeutics·Nicolas PierreEdouard Louis
Aug 18, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Qingqing LiuNoam Harpaz

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