Treatments for dry age-related macular degeneration and Stargardt disease: a systematic review.

Health Technology Assessment : HTA
Norman WaughNoemi Lois

Abstract

Age-related macular degeneration (AMD) is the leading cause of visual loss in older people. Advanced AMD takes two forms, neovascular (wet) and atrophic (dry). Stargardt disease (STGD) is the commonest form of inherited macular dystrophy. To carry out a systematic review of treatments for dry AMD and STGD, and to identify emerging treatments where future NIHR research might be commissioned. Systematic review. We searched MEDLINE, EMBASE, Web of Science and The Cochrane Library from 2005 to 13 July 2017 for reviews, journal articles and meeting abstracts. We looked for studies of interventions that aim to preserve or restore vision in people with dry AMD or STGD. The most important outcomes are those that matter to patients: visual acuity (VA), contrast sensitivity, reading speed, ability to drive, adverse effects of treatment, quality of life, progression of disease and patient preference. However, visual loss is a late event and intermediate predictors of future decline were accepted if there was good evidence that they are strong predictors of subsequent visual outcomes. These include changes detectable by investigation, but not necessarily noticed by people with AMD or STGD. ClinicalTrials.gov, the World Health Organization ...Continue Reading

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Citations

Mar 12, 2020·Cell and Tissue Banking·Alireza Baradaran-RafiiBabak Arjmand
Nov 25, 2018·International Journal of Molecular Sciences·Marina RoizenblattPeter L Gehlbach
Aug 29, 2019·Expert Opinion on Therapeutic Patents·Clemente Capasso, Jean-Yves Winum
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Oct 4, 2020·Experimental Eye Research·Chang-Jun ZhangZi-Bing Jin
Apr 14, 2021·Ophthalmology and Therapy·Dewi Fathin RomdhoniyyahNicholas A V Beare
Jun 8, 2021·The Cochrane Database of Systematic Reviews·Christin Henein, David Hw Steel

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