Treatments for microcystic adnexal carcinoma--A review

The Journal of Dermatological Treatment
Soham P ChaudhariPrakash J Chaudhari

Abstract

Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous neoplasm presenting as a slow-growing, indurated nodule, papule or plaque. Clinically, the lesion can blend into the surrounding skin, obscuring borders and consequently delaying diagnosis histologically. Surgical and histologic techniques that emphasize examination of all margins may optimize management through early diagnosis and prevention of recurrences. This review aims to assess the current surgical and histology techniques that result in lower rates of tumor recurrence and, consequently, better clinical outcomes. A literature search of the PubMed database was conducted to identify studies examining wide local excision (WLE), Mohs micrographic surgery (MMS), radiotherapy (RT) and chemotherapy in the treatment of MAC. WLE had a high likelihood of positive margins and local recurrence. MMS was found to have the lowest recurrence rates. Definitive RT could be considered for elderly patients or those who are poor surgical candidates, as large surgical defects may be required to obtain free margins with either WLE or MMS. Chemotherapy was found to be ineffective. Complete margin evaluation with MMS permits complete tumor removal with subsequently low recurrence ...Continue Reading

References

May 1, 1976·Oral Surgery, Oral Medicine, and Oral Pathology·S Gulmen, P A Pullon
Sep 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·N D FutranJ E Muhlbauer
Jul 1, 1991·The Annals of Otology, Rhinology, and Laryngology·W T YuhK D Dolan
Mar 1, 1989·The Journal of Dermatologic Surgery and Oncology·C S BirkbyD C Whitaker
Jul 1, 1989·The Journal of Dermatologic Surgery and Oncology·W C ChowR G Geronemus
Dec 1, 1989·Plastic and Reconstructive Surgery·M H MayerF W Shagets
Aug 1, 1987·Annals of Plastic Surgery·J C HammN A Swanson
Jun 1, 1985·The American Journal of Surgical Pathology·P H CooperD A Katz
Nov 1, 1984·The Journal of Dermatologic Surgery and Oncology·H E FleischmannB J Nickoloff
Nov 1, 1995·The Laryngoscope·C M Bier-LaningA J Duvall
Jul 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M L RobinsonJ B Roberson
Apr 1, 1995·Archives of Ophthalmology·R J HesseE Griener
Nov 1, 1994·International Journal of Dermatology·P G Hazen, J Bass
Nov 1, 1994·The Journal of Dermatologic Surgery and Oncology·J P McAlvanyW White
Jul 1, 1994·The Journal of Dermatologic Surgery and Oncology·M K BurnsL H Goldberg
Feb 1, 1994·Southern Medical Journal·C W Lober, G G Larbig
Nov 1, 1993·Journal of the American Academy of Dermatology·T S SebastienT M Johnson
Feb 1, 1996·Archives of Otolaryngology--head & Neck Surgery·E M BillingsleyM E Maloney
Apr 3, 1999·Journal of Cutaneous Pathology·C A AntleyB R Smoller
Jul 30, 1999·Journal of the American Academy of Dermatology·P M FriedmanP Robins
Jun 10, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·P CarrollC W Brown
Jun 10, 2000·International Journal of Dermatology·H P SchwarzeJ Bazex
Nov 14, 2000·Archives of Dermatology·K ChillerR C Grekin
May 31, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Hisashi Ohtsuka, Shogo Nagamatsu
Feb 25, 2003·Head & Neck·Jeannine M SteinPhilip Bailin
May 17, 2003·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Nicole RotterWolfgang J Issing
Jun 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Nil CulhaciEmel Dikicioğlu
Oct 4, 2003·ANZ Journal of Surgery·Stephen Salerno, Patricia Terrill
Apr 15, 2004·Ophthalmic Plastic and Reconstructive Surgery·T OngE Calonje
Feb 5, 2005·Journal of the American Academy of Dermatology·Igal LeibovitchRobert Paver
Mar 22, 2005·Ophthalmic Plastic and Reconstructive Surgery·Colin I ClementAlistair G B Lochhead
Jun 1, 2005·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Karl T BeerRichard Greiner
Jun 9, 2005·International Journal of Dermatology·Amor KhachemouneDarlene S Johnson
Nov 26, 2005·The British Journal of Dermatology·I LeibovitchS Richards
Jan 24, 2006·Auris, Nasus, Larynx·Juntian LangKazuo Ishikawa
Feb 24, 2006·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Igal LeibovitchDinesh Selva
Jun 10, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·María J Gomez-MaestraSoledad Peña
Feb 26, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ioulios PalamarasRichard J Barlow
Oct 21, 2010·Journal of Medical Imaging and Radiation Oncology·Siddhartha BaxiMichael Poulsen
Aug 24, 2013·Journal of Plastic Surgery and Hand Surgery·Lawrence H C KimChristopher Henderson

❮ Previous
Next ❯

Citations

Aug 10, 2016·JAAD Case Reports·David Thomas HarveyBarry J Roseman
Jan 22, 2019·The Journal of Dermatology·Takahiro HagaSetsuya Aiba
Jan 9, 2020·Bioscience Reports·Lei ZhangHongbao Cao
Dec 21, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·May P ChanPaul W Harms
Jun 3, 2021·International Journal of Molecular Sciences·Iga PłachtaPiotr Rutkowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Dermatology
Igal LeibovitchRobert Paver
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
S SnowA Landeck
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
John K WildemoreTatyana R Humphreys
© 2021 Meta ULC. All rights reserved