Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy

Neuropsychiatric Disease and Treatment
Larry D MorriesTheodore A Henderson

Abstract

Traumatic brain injury (TBI) is a growing health concern affecting civilians and military personnel. In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, and hyperbaric oxygen therapy. All available literature suggests a marginal benefit with prolonged treatment courses. An emerging modality of treatment is near-infrared (NIR) light, which has benefit in animal models of stroke, spinal cord injury, optic nerve injury, and TBI, and in human trials for stroke and TBI. The extant literature is confounded by variable degrees of efficacy and a bewildering array of treatment parameters. Some data indicate that diodes emitting low-level NIR energy often have failed to demonstrate therapeutic efficacy, perhaps due to failing to deliver sufficient radiant energy to the necessary depth. As part of this review, we present a retrospective case series using high-power NIR laser phototherapy with a Class IV laser to treat TBI. We demonstrate greater clinical efficacy with higher fluence, in contrast to the bimodal model of efficacy previously proposed. In ten patients with chronic TBI (average time since injury 9.3 years) given ten treatments over the course of 2 ...Continue Reading

Citations

Nov 21, 2018·Journal of Biomechanical Engineering·Michael PapacharalambousBoris Rubinsky
Feb 24, 2017·Reviews in the Neurosciences·Farzad Salehpour, Seyed Hossein Rasta
Jul 12, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Cathaleen MadsenTracey Pérez Koehlmoos
Aug 18, 2020·Journal of Lasers in Medical Sciences·Letícia Lemes SassoRafael Inácio Barbosa
Oct 17, 2017·Frontiers in Psychiatry·Theodore A Henderson, Larry D Morries
Jun 13, 2018·Bioengineering·Marcelie Priscila de Oliveira RossoRogério Leone Buchaim
May 11, 2018·BMC Neuroscience·Oksana PolesskayaMax Myakishev-Rempel
Jul 12, 2019·World Journal of Stem Cells·Federica FacchinCarlo Ventura
Jul 6, 2021·Aging and Disease·Damir NizamutdinovJason H Huang
Jul 3, 2021·Scientific Reports·Agnes S ChanMei-Chun Cheung

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