Apr 9, 2016

Tree inference for single-cell data

BioRxiv : the Preprint Server for Biology
Katharina JahnNiko Beerenwinkel

Abstract

Understanding the mutational heterogeneity within tumours is a keystone for the development of efficient cancer therapies. Here, we present SCITE, a stochastic search algorithm to identify the evolutionary history of a tumour from noisy and incomplete mutation profiles of single cells. SCITE comprises a flexible MCMC sampling scheme that allows the user to compute the maximum-likelihood mutation history, to sample from the posterior probability distribution, and to estimate the error rates of the underlying sequencing experiments. Evaluation on real cancer data and on simulation studies shows the scalability of SCITE to present-day single-cell sequencing data and improved reconstruction accuracy compared to existing approaches.

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Mentioned in this Paper

Trees (plant)
Reconstructive Surgical Procedures
Neoplasms
Evaluation
Cancer Treatment
Sequencing
Dorsal
Simulation
Malignant Neoplasms
Genome Sequencing

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