Trefoil factor 1 is required for the commitment programme of mouse oxyntic epithelial progenitors

Gut
Sherif M KaramM-C Rio

Abstract

Trefoil factor 1 (TFF1/pS2) is a major secretory product of the stomach and TFF1 knockout mice constantly develop adenomas and occasional carcinomas in the pyloric antrum. To analyse the role of TFF1 in the differentiation of gastric epithelial cell lineages using oxyntic mucosae from normal and TFF1 knockout mice. The various cell lineages were labelled using specific markers of pit, neck, parietal, and enteroendocrine cells. Patterns of TFF1, TFF2, and TFF3 expressions were defined using western blotting, immunohistochemistry, and/or immunogold electron microscopy. In normal mice, starting from postnatal day 1 (P1), TFF1 and TFF2 were produced by mucus secreting cells of the developing epithelium. At P7, TFF3 expression occurred in pit and parietal cells. When oxyntic glands were compartmentalised, at P21 and in older mice, TFF1 and TFF2 were expressed in pit and neck cells, respectively, and TFF3 was no longer in parietal cells but became a feature of zymogenic cells. In TFF1 deficient mice, alteration of oxyntic epithelial differentiation became obvious at P21, showing significant amplification of pit cells at the expense of parietal cells. At the molecular level, lack of TFF1 induced dramatic inhibition of TFF2 expression ...Continue Reading

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Citations

May 18, 2005·Biochemical and Biophysical Research Communications·Niklas AnderssonClaes Ohlsson
Aug 28, 2007·Nature Reviews. Cancer·Kelly A Green, Jason S Carroll
Dec 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Genevieve KoPietro De Camilli
Nov 3, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Melanie A GreeleyCharles G Plopper
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Mar 19, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Faïza MaloumNathalie Perreault
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