Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α

Oncotarget
Shuo DiaoYinghui Xu

Abstract

Trefoil factor 3 (TFF3) plays significant roles in several solid tumors. However, the expression pattern and function of TFF3 in glioblastoma (GBM) have not been reported. Here, we report that expression level of TFF3 significantly elevated in glioma and correlated with the prognosis of glioma patients. Then we found TFF3 promotes proliferation, invasion, and migration and inhibits apoptosis of glioma cells in vitro, and delayed tumor progression in subcutaneous xenograft nude mice, and prolonged the median survival time in orthotopic xenograft mice. Moreover, knockdown of TFF3 reduced the expression of HIF-1α through a hypoxia-independent manner. These findings suggest that targeting TFF3 may offer a novel strategy for therapeutic intervention of malignant gliomas.

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Methods Mentioned

BETA
Flow cytometry
co-IP
xenograft
xenografts
immunoprecipitation
protein assay
ELISA
transfection
biopsy

Software Mentioned

SPSS

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