Trefoil factor 3 shows anti-inflammatory effects on activated microglia

Cell and Tissue Research
Philipp ArnoldRalph Lucius

Abstract

Microglial cells are a major source of pro-inflammatory cytokines during central nervous system (CNS) inflammation. They can develop a pro-inflammatory M1 phenotype and an anti-inflammatory M2 phenotype. Shifting the phenotype from M1 to M2 might be an important mechanism to overcome CNS inflammation and to prevent or reduce neuronal damage. Here, we demonstrate that the anti-inflammatory protein trefoil factor 3 (TFF3) is secreted by astrocytes and that its transcription is significantly reduced after incubation with lipopolysaccharide (LPS). Moreover, we demonstrate that microglial cells cultured in the presence of TFF3 show reduced expression and secretion of pro-inflammatory cytokines after LPS stimulation.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S SuemoriD K Podolsky
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Nov 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J C ProbstG F Jirikowski
Feb 3, 1998·Cellular and Molecular Life Sciences : CMLS·L Thim
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·A WiedeW Hoffmann
Nov 11, 1999·Cell and Tissue Research·W JaglaW Hoffmann
Feb 5, 2000·The Journal of Pathology·E dos Santos SilvaP Gött
May 23, 2000·Human Pathology·D A DevineW A Bonass
Jun 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W JaglaW Hoffmann
Mar 11, 2008·The Journal of Biological Chemistry·Friedrich P PaulsenSaadettin Sel
Dec 25, 2009·Acta Neuropathologica·Hartwig Wolburg, Werner Paulus
Jan 16, 2010·International Journal of Immunopathology and Pharmacology·H WilmsR Lucius
Dec 15, 2010·European Journal of Cell Biology·Athena ChalarisJürgen Scheller
Jul 20, 2011·The International Journal of Developmental Biology·Stefan LiebnerHartwig Wolburg
Dec 21, 2011·Journal of Periodontology·Ponlatham ChaiyaritAndrew S Giraud
Jan 31, 2012·Pancreas·Naomi J GuppyMalcolm R Alison
Aug 8, 2012·Nature Medicine·Jan Heinrichsdorff, Jerrold M Olefsky
Jan 30, 2013·PloS One·Sanhita RoyAlan M Tartakoff
May 11, 2013·The International Journal of Biochemistry & Cell Biology·Dereck E W ChattertonPer Torp Sangild
Mar 5, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·J F WuH Q Zhang
May 10, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Philipp ArnoldChristoph Becker-Pauly
Jun 13, 2015·Progress in Neurobiology·Rafael Franco, Diana Fernández-Suárez

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Citations

Feb 28, 2020·Experimental and Therapeutic Medicine·He-Ping LiKai Zhong
Jan 29, 2021·World Journal of Gastroenterology : WJG·Yun HuangShi-Nan Nie
Jun 19, 2021·Journal of Medicinal Chemistry·Nayara Braga EmidioMarkus Muttenthaler
Jun 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ji WangYan Wu

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