PMID: 9447240Feb 3, 1998Paper

Trefoil peptides: from structure to function

Cellular and Molecular Life Sciences : CMLS
L Thim

Abstract

The unique structure in which six cysteine residues in a sequence of 38 or 39 amino acid residues form three disulphide bonds in a 1-5, 2-4 and 3-6 configuration constitutes the basic elements of a trefoil domain. Today three mammalian trefoil factors (TFF1, TFF2 and TFF3) containing one or two trefoil domains are known. Trefoil factors are usually associated with the mucin layer of the gastrointestinal tract. Early studies on trefoil factors concentrated on structure elucidation and sites of expression in health and disease, whereas studies over the last 3-5 years have focused on the mechanism of action and the search for specific receptors. This review summarises our present knowledge of trefoil peptide structures, their sites of expression, and their protection and repair functions, with a focus on the mechanism by which these peptides exert their biological function.

Citations

Dec 28, 2007·Pharmaceutical Research·Yogeeta NarkarJoseph R Robinson
Feb 14, 2004·Genomics·Aaron C BrownDerry C Roopenian
Jun 1, 2000·Regulatory Peptides·L Thim, E Mørtz
Feb 24, 2000·Biochimica Et Biophysica Acta·E D Al-azzehP Gött
Sep 18, 1998·Biochimica Et Biophysica Acta·S RibierasM C Rio
Aug 3, 2002·European Journal of Clinical Investigation·L ThimS S Poulsen
Apr 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Daniel R RadiloffXiao-Fan Wang
Sep 14, 2007·Annual Review of Physiology·David J ThorntonMichael A McGuckin
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ludmila KhailovaBohuslav Dvorak
Sep 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gaurav SyalJonathan A Dranoff
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·A WiedeW Hoffmann
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·M OertelW Hoffmann
Apr 19, 2003·American Journal of Respiratory Cell and Molecular Biology·Nikolaos M NikolaidisMarc E Rothenberg
Oct 3, 2013·PloS One·Yuan XueYongsheng Chang
Jul 13, 2007·Journal of Perinatal Medicine·Lei ShiJuan-Li Xi
Sep 8, 2010·World Journal of Gastroenterology : WJG·Giulia RodaEnrico Roda
Nov 28, 2002·Clinical and Experimental Immunology·C CiacciY R Mahida
Nov 16, 2010·Cellular and Molecular Life Sciences : CMLS·M Lubka-PathakT Schimmang
Jan 7, 2011·World Journal of Surgery·Funmi AyanbuleDavid H Berger

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