Treg functional stability and its responsiveness to the microenvironment

Immunological Reviews
Joseph BarbiFan Pan

Abstract

Regulatory T cells (Tregs) prevent autoimmunity and tissue damage resulting from excessive or unnecessary immune activation through their suppressive function. While their importance for proper immune control is undeniable, the stability of the Treg lineage has recently become a controversial topic. Many reports have shown dramatic loss of the signature Treg transcription factor Forkhead box protein 3 (Foxp3) and Treg function under various inflammatory conditions. Other recent studies demonstrate that most Tregs are extremely resilient in their expression of Foxp3 and the retention of suppressive function. While this debate is unlikely to be settled in the immediate future, improved understanding of the considerable heterogeneity within the Foxp3(+) Treg population and how Treg subsets respond to ranging environmental cues may be keys to reconciliation. In this review, we discuss the diverse mechanisms responsible for the observed stability or instability of Foxp3(+) Treg identity and function. These include transcriptional and epigenetic programs, transcript targeting, and posttranslational modifications that appear responsive to numerous elements of the microenvironment. These mechanisms for Treg functional modulation add to...Continue Reading

References

Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Feb 20, 2003·The Journal of Experimental Medicine·Iris CaramalhoJocelyne Demengeot
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah J KasprowiczSteven F Ziegler
Aug 29, 2003·Expert Opinion on Biological Therapy·Yasmine Belkaid
Nov 25, 2003·Current Opinion in Immunology·Chandrashekhar Pasare, Ruslan Medzhitov
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elise ChiffoleauLaurence A Turka
Jun 3, 2004·Nature Reviews. Immunology·Kazuo SugamuraAndrew D Weinberg
Jul 28, 2004·Trends in Immunology·Joanne Elliott, James A Johnston
May 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qian ZhangMariusz A Wasik
May 20, 2005·European Journal of Immunology·Giovanna RoncadorAlison H Banham
Aug 27, 2005·Science·Guangyong PengRong-Fu Wang
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natasha K CrellinMegan K Levings
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth A WohlfertRobert B Clark
Jan 21, 2006·The Journal of Clinical Investigation·Roger P M SutmullerGosse J Adema
Feb 16, 2006·Immunology·Christian DejacoMichael Schirmer
Mar 16, 2006·Blood·Xavier ValenciaPeter E Lipsky
Apr 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc A GavinAlexander Y Rudensky
Apr 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Haiying LiuFoo Y Liew
May 30, 2006·Molecular Cancer Therapeutics·Lee M Ellis
Sep 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L ChenA Chong
Dec 13, 2006·European Journal of Immunology·Jun WangRené E M Toes
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew A BurchillMichael A Farrar
Dec 23, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vinodh PillaiNitin J Karandikar
Jan 30, 2007·The Journal of Biological Chemistry·Debra A MacKenzieChristine M Seroogy
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carolin DanielJuergen M Stein
Feb 15, 2007·PLoS Biology·Stefan FloessJochen Huehn
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bin LiMark I Greene
Mar 23, 2007·Nature·Masahiro OnoShimon Sakaguchi
Jun 27, 2007·The Journal of Experimental Medicine·Hyoung-Pyo Kim, Warren J Leonard
Jul 11, 2007·The Journal of Experimental Medicine·Cheng-Ming SunYasmine Belkaid

❮ Previous
Next ❯

Citations

Jan 18, 2016·Current Opinion in Immunology·Abigail E Overacre, Dario Aa Vignali
Apr 10, 2014·Immunological Reviews·Andrew J Caton, Katherine A Weissler
Mar 29, 2016·Immunological Investigations·Salimeh EbrahimnezhadMohammad Hossein Karimi
Jun 19, 2015·Immunological Reviews·Joseph BarbiFan Pan
Jun 17, 2015·Biochemical Pharmacology·Ling-Jun HoJenn-Haung Lai
Jul 8, 2015·Nature Communications·Michelle L MillerAnita S Chong
Apr 20, 2017·Frontiers in Immunology·Sharvan Sehrawat, Barry T Rouse
Oct 28, 2017·Journal of Translational Medicine·Jeong-Hee Yang, Seok-Chan Eun
Jul 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siddheshvar BhelaBarry T Rouse
Aug 5, 2017·Immunotherapy·Xuehui HeIrma Joosten
Jan 23, 2019·Yonsei Medical Journal·Min Kyung JungEui Cheol Shin
Nov 3, 2017·Immune Network·Min Kyung JungEui-Cheol Shin
Jun 18, 2017·Cold Spring Harbor Perspectives in Biology·Kevin H Toomer, Thomas R Malek
Dec 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·James D FisherSteven R Little
Feb 9, 2020·Expert Opinion on Biological Therapy·Shuo WangJun Ren
Mar 12, 2020·Ocular Immunology and Inflammation·Peijun ZhangQing Chang
Aug 28, 2019·Experimental and Therapeutic Medicine·Changfu LiuZengxi Xin
Aug 29, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y LiX Xu
Sep 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mario GalganiGiuseppe Matarese
May 17, 2017·The Journal of Experimental Medicine·Victoria S PellyMark S Wilson
Mar 16, 2017·Nature Communications·Stephanie Downs-CannerNataša Obermajer
Apr 30, 2017·Oncology Letters·Denise Faria Galano CarvalhoEdson Garcia Soares
Oct 28, 2017·Frontiers in Immunology·Brett Eugene PhillipsNick Giannoukakis
Feb 16, 2019·BioMed Research International·Antonella AgodiMassimiliano Veroux
Jun 13, 2019·Oncology Letters·Natalya Lisovska, Nasrulla Shanazarov
Jul 16, 2020·Communications Biology·Rebeca Arroyo HorneroJoanna Hester

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Current Topics in Microbiology and Immunology
Michael DelacherJochen Huehn
Nature Reviews. Immunology
Shimon SakaguchiDavid A Hafler
Trends in Molecular Medicine
Maria da Silva Martins, Ciriaco A Piccirillo
© 2021 Meta ULC. All rights reserved