PMID: 7334500Dec 1, 1981Paper

Trehalase activity in genetically diabetic mice (serum, kidney, and liver)

Journal of Medical Genetics
F C BaumannJ Labat-Robert

Abstract

Trehalase activity was determined in serum, liver, and kidney in alloxan treated Swiss mice and in homozygous (Ob/Ob, Db/Db) and heterozygous (Ob/+, Db/m+) diabetic mice. Both alloxan and genetic diabetic mice exhibited a large increase in serum and liver trehalase activity with no change in kidney trehalase activity. The heterozygotes (Ob/+, Db/m+) showed only a slight increase of enzyme activity. Further quantitative differences were noticed between the genetic and alloxan diabetic animals. The liver enzyme activity increased from 10- to more than 20-fold in the liver of the homozygous Ob/Ob and Db/Db strains and only 3-fold (not significant compared to controls) in the alloxan treated animals. The above results suggest a regulatory relationship between the genes coding for trehalase and the enzymes of glucose metabolism activity involved in the development of the metabolic anomalies of diabetes. The structural gene for trehalase may well have survived elimination of selective pressure during phylogenesis and remained part of a co-regulated group of glucose metabolising enzymes. This could explain its sensitivity to mutations affecting glucose metabolism and its sensitivity to insulin directed regulatory mechanisms.

References

Aug 15, 1979·The Biochemical Journal·P KernL Robert
Dec 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F DemelierJ Labat
Jul 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·B Sacktor
Apr 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·L C Eze, D A Evans
Jun 27, 1969·Biochemical and Biophysical Research Communications·B Sacktor, S J Berger

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Citations

Mar 28, 2020·Critical Reviews in Food Science and Nutrition·Amar D E Van LaarJohn Van Camp

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