Trehalose protects Saccharomyces cerevisiae from lipid peroxidation during oxidative stress

Biochimica Et Biophysica Acta
R S HerdeiroElis Cristina Araujo Eleutherio

Abstract

Aiming to focus the protective role of the sugar trehalose under oxidative conditions, two sets of Saccharomyces cerevisiae strains, having different profiles of trehalose synthesis, were used. Cells were treated either with a 10% trehalose solution or with a heat treatment (which leads to trehalose accumulation) and then exposed either to menadione (a source of superoxide) or to tert-butylhydroperoxide (TBOOH). According to our results, trehalose markedly increased viability upon exposure to menadione stress, which seems to be correlated with decrease in lipid peroxidation levels. The protective effect of trehalose against oxidative damage produced by menadione was especially efficient under SOD1 deficiency. On the other hand, this sugar does not seem to participate of the mechanism of acquisition of tolerance against TBOOH, since trehalose pretreatment (addition of external trehalose) was not capable of increase cell survival. Therefore, trehalose plays a role in protecting cells, especially membranes, from oxidative injuries. However, this mechanism of defense is dependent on the type of oxidative stress to which cells are submitted.

References

Jun 9, 1988·Biochimica Et Biophysica Acta·J H CroweT J Anchordoguy
Mar 1, 1993·Journal of General Microbiology·J Flattery-O'BrienI W Dawes
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J F DavidsonR H Schiestl
Feb 1, 1996·Molecular Microbiology·P Moradas-FerreiraW Mager
Feb 5, 2000·Nature Biotechnology·N GuoF Levine
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Feb 28, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Willem F WolkersJohn H Crowe
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A B RichardsM Kurimoto
Nov 25, 2003·Cell Stress & Chaperones·Elenilda de Jesus PereiraElis Cristina Araujo Eleutherio
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Janine Mauzeroll, Allen J Bard
Aug 10, 2004·The Journal of Experimental Biology·Qiaofang Chen, Gabriel G Haddad
Oct 7, 2004·Critical Reviews in Food Science and Nutrition·Joye K WillcoxGeorge L Catignani

❮ Previous
Next ❯

Citations

Jan 19, 2011·Applied Microbiology and Biotechnology·Eduardo T V TrevisolElis C A Eleutherio
May 4, 2012·Applied Microbiology and Biotechnology·Guillaume LemetaisPatrick Gervais
May 7, 2013·Applied Microbiology and Biotechnology·Jidong LiuJian Chen
Oct 13, 2009·Journal of Industrial Microbiology & Biotechnology·Bing-Zhi LiYing-Jin Yuan
Feb 5, 2013·Journal of Industrial Microbiology & Biotechnology·Xiang-Yang GeXiang Chen
Jun 1, 2011·World Journal of Microbiology & Biotechnology·Drauzio E N Rangel
Feb 19, 2013·World Journal of Microbiology & Biotechnology·Melchor Arellano-PlazaAlfredo Saavedra-Molina
Jun 23, 2010·Human Molecular Genetics·Benjamin R UnderwoodDavid C Rubinsztein
Jun 10, 2011·Clinical Ophthalmology·Jacques Luyckx, Christophe Baudouin
Oct 27, 2007·Redox Report : Communications in Free Radical Research·Marcia Farias RolimAlberto Schanaider
Nov 20, 2008·Redox Report : Communications in Free Radical Research·Diana MarianiMarcos Dias Pereira
Sep 15, 2011·Journal of Natural Medicines·Carmelita Gomes da SilvaCláudia Moraes de Rezende
May 29, 2008·Journal of Industrial Microbiology & Biotechnology·Carolina ElszteinMarcos Antonio de Morais
Aug 31, 2014·Applied Microbiology and Biotechnology·Sebastien DupontLaurent Beney
Jul 27, 2014·Biotechnology Letters·Hua-xiang Li, Byong H Lee
Jul 11, 2013·Journal of Bioscience and Bioengineering·Iulia BleoancaRegina de Andrade Menezes
Jul 15, 2011·Micron : the International Research and Review Journal for Microscopy·Po-Lin ChiuThomas Walz
Jul 14, 2010·International Journal of Food Microbiology·Sara LandolfoIlaria Mannazzu
Apr 5, 2015·Current Opinion in Biotechnology·Jonathan A CrayJohn E Hallsworth
Mar 31, 2009·Biotechnology Advances·Zhenming ChiTong Zhang
Oct 7, 2008·Biochemical and Biophysical Research Communications·Toshihiko Ogura
Jul 8, 2008·Biochimica Et Biophysica Acta·Débora da Costa Morato NeryElis Cristina Araújo Eleutherio
May 22, 2007·Mycological Research·Barbara Wolska-MitaszkoKatarzyna Pszeniczna
Apr 4, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M B FrançaE C A Eleutherio
Dec 17, 2014·Microbiology·Dorota Kuczyńska-WiśnikEwa Laskowska
Jan 2, 2014·Biochimica Et Biophysica Acta·Eduardo T V TrevisolElis C A Eleutherio
Jun 17, 2015·Mechanisms of Ageing and Development·Kwanjeera WanichthanarakDina Petranovic
Sep 12, 2014·Current Genetics·Elis EleutherioRayne Magalhães
Jun 24, 2015·Current Genetics·Drauzio E N RangelJohn E Hallsworth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved