TREM-1 and TREM-2 Expression on Blood Monocytes Could Help Predict Survival in High-Grade Glioma Patients.

Mediators of Inflammation
K KluckovaMaria Bucova

Abstract

In recent years, the role of the modern inflammatory markers TREM-1 (triggering receptors expressed on myeloid cells) and HMGB1 (high mobility group box 1 protein) in tumorigenesis has begun to be studied. Their role in gliomas is not clear. The aim of our study was to find the role of inflammation in gliomas. Patients and Methods. In 63 adult patients with gliomas and 31 healthy controls, the expressions of TREM-1 and TREM-2 on CD14+ blood cells (method: flow cytometry) and the levels of soluble sTREM-1, HMGB1, IL-6, and IL-10 (Elisa tests) were analyzed. Cox proportional hazard analysis showed that a TREM-1/TREM-2 ratio was associated with reduced overall survival (HR = 1.001, P = 0.023). Patients with a TREM-1/TREM-2 ratio above 125 survived significantly shorter than patients with a TREM-1/TREM-2 ratio below 125. The percentage of CD14+ TREM-1+ cells was strongly associated with a plasma IL-6/IL-10 ratio (positively) and with IL-10 (negatively). Conversely, we found a higher percentage of CD14+ TREM-2+ monocytes in better surviving patients; these cells could downregulate the exaggerated inflammation and potentiate the phagocytosis in the tumor. The serum levels of HMGB1 negatively correlated with the percentage of CD14+ TR...Continue Reading

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Citations

Jan 7, 2021·Journal of Leukocyte Biology·Albert C SekHelene F Rosenberg
Jan 29, 2021·Expert Opinion on Therapeutic Patents·Harbinder SinghDevendra K Agrawal
Jan 31, 2021·International Journal of Molecular Sciences·Robert DaltonErika A Eksioglu
Mar 23, 2021·Frontiers in Genetics·Nuria PlanellDavid Gomez-Cabrero

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Methods Mentioned

BETA
flow
ELISA
flow cytometry

Software Mentioned

KALUZA

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