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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Molecular Neurodegeneration

Oct 19, 2017

Shane BemillerBruce T Lamb

Abstract

Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the multifaceted roles of TREM2 in regulating extracellu...read more

Mentioned in this Paper

Study
Biochemical Pathway
Tauopathies
Stress-activated Protein Kinase Signaling Cascade
APP protein, human
Hyperphosphorylation
Physiological Stress
Extracellular
Protoplasm
Aggregation
3
1
101
Paper Details
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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Molecular Neurodegeneration

Oct 19, 2017

Shane BemillerBruce T Lamb

PMID: 29037207

DOI: 10.1186/s13024-017-0216-6

Abstract

Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the multifaceted roles of TREM2 in regulating extracellu...read more

Mentioned in this Paper

Study
Biochemical Pathway
Tauopathies
Stress-activated Protein Kinase Signaling Cascade
APP protein, human
Hyperphosphorylation
Physiological Stress
Extracellular
Protoplasm
Aggregation
3
1
101

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