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TREM2, Microglia, and Neurodegenerative Diseases

Trends in Molecular Medicine

Apr 27, 2017

Felix L YehMorgan Sheng

Abstract

Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β (Aβ) plaques and intraneuronal hyperphosphorylated tau aggregates. Genetic variants of TREM2 (triggering ...read more

Mentioned in this Paper

Study
Familial Alzheimer Disease (FAD)
Pathogenic Aspects
Immune System
Pathogenesis
APP protein, human
Extracellular
Brain
Cessation of Life
Nerve Degeneration
20
3
1
284
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TREM2, Microglia, and Neurodegenerative Diseases

Trends in Molecular Medicine

Apr 27, 2017

Felix L YehMorgan Sheng

PMID: 28442216

DOI: 10.1016/j.molmed.2017.03.008

Abstract

Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β (Aβ) plaques and intraneuronal hyperphosphorylated tau aggregates. Genetic variants of TREM2 (triggering ...read more

Mentioned in this Paper

Study
Familial Alzheimer Disease (FAD)
Pathogenic Aspects
Immune System
Pathogenesis
APP protein, human
Extracellular
Brain
Cessation of Life
Nerve Degeneration
20
3
1
284

Similar Papers Found In These Feeds

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Paper Details
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  • Citations27
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