TREM2: Modulator of Lipid Metabolism in Microglia.

Neuron
Eyiyemisi C DamisahJaime Grutzendler

Abstract

Lipid-processing mechanisms during demyelination are poorly understood. In this issue of Neuron,Nugent et al. (2020) show by cell-specific lipidomics that Trem2 deficiency leads to cholesterol ester (CE) overload in microglia. This is mediated by misregulation of lipid metabolism genes and is rescued by modulating CE synthesis or efflux.

References

Apr 22, 2015·The Journal of Clinical Investigation·Pietro Luigi PolianiMarco Colonna
Sep 17, 2015·The Journal of Biological Chemistry·Yuka AtagiGuojun Bu
Aug 13, 2017·Cell·Tyler K UllandMarco Colonna
Nov 25, 2017·Biological Psychiatry·Carlo CondelloJaime Grutzendler
Jan 6, 2018·Science·Ludovico Cantuti-CastelvetriMikael Simons
Mar 21, 2018·Nature Neuroscience·Robert A HillJaime Grutzendler

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