TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia

PloS One
Yoko MoriShu-Ichi Ueno

Abstract

TREM2 and TYROBP are causal genes for Nasu-Hakola disease (NHD), a rare autosomal recessive disease characterized by bone lesions and early-onset progressive dementia. TREM2 forms a receptor signaling complex with TYROBP, which triggers the activation of immune responses in macrophages and dendritic cells, and the functional polymorphism of TREM2 is reported to be associated with neurodegenerative disorders such as Alzheimer's disease (AD). The objective of this study was to reveal the involvement of TYROBP and TREM2 in the pathophysiology of AD and schizophrenia. We investigated the mRNA expression level of the 2 genes in leukocytes of 26 patients with AD and 24 with schizophrenia in comparison with age-matched controls. Moreover, we performed gene association analysis between these 2 genes and schizophrenia. No differences were found in TYROBP mRNA expression in patients with AD and schizophrenia; however, TREM2 mRNA expression was increased in patients with AD and schizophrenia compared with controls (P < 0.001). There were no genetic associations of either gene with schizophrenia in Japanese patients. TREM2 expression in leukocytes is elevated not only in AD but also in schizophrenia. Inflammatory processes involving TREM2 ...Continue Reading

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Citations

Apr 17, 2017·Journal of Psychiatric Research·Yuki OzakiShu-Ichi Ueno
Feb 23, 2017·Journal of Alzheimer's Disease : JAD·Kiyohiro YamazakiShu-Ichi Ueno
Nov 23, 2016·The International Journal of Neuroscience·Jie HanHaiyan Lou
May 1, 2018·Molecular Neurobiology·Gerwyn MorrisBasant K Puri
May 1, 2016·Journal of Neural Transmission·Yuta YoshinoShu-Ichi Ueno
Aug 5, 2017·Molecular Neurodegeneration·Taylor R JayGary E Landreth
Aug 28, 2020·International Journal of Molecular Sciences·Huifangjie LiJinbin Xu
Oct 5, 2018·Molecular Neurodegeneration·Wei Cao, Hui Zheng
Jul 19, 2020·Molecular Biology Reports·Gamze GuvenNihan Erginel-Unaltuna
Aug 21, 2020·Molecular Neurobiology·Shinichiro OchiShu-Ichi Ueno
Nov 8, 2017·Psychiatry and Clinical Neurosciences·Tomoko SaoShu-Ichi Ueno
Nov 30, 2018·Acta Neuropathologica·José Luis MolinuevoKaj Blennow
Apr 16, 2018·Journal of Neuroinflammation·Jiang-Tao Li, Ying Zhang
Jan 3, 2021·Journal of Alzheimer's Disease : JAD·Hiroshi KumonShu-Ichi Ueno
Apr 9, 2021·Journal of Molecular Neuroscience : MN·Priyanka NaguVineet Mehta

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Methods Mentioned

BETA
Genotyping
blood draw
PCR

Software Mentioned

SPSS
Power
StepOnePlus
StepOne
HaploView

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