Tremor in multiple sclerosis is associated with cerebello-thalamic pathology

Journal of Neural Transmission
Frederique BoonstraA Van der Walt

Abstract

Tremor in people with multiple sclerosis (MS) is a frequent and debilitating symptom with a relatively poorly understood pathophysiology. To determine the relationship between clinical tremor severity and structural magnetic resonance imaging parameters. Eleven patients with clinically definite MS and right-sided upper limb tremor were studied. Tremor severity was assessed using the Bain score (overall severity, writing, and Archimedes spiral drawing). Cerebellar dysfunction was assessed using the Scale for the Assessment and Rating of Ataxia. Dystonia was assessed using the Global Dystonia Scale adapted for upper limb. For all subjects, volume was calculated for the thalamus from T1-weighted volumetric scans using Freesurfer. Superior cerebellar peduncle (SCP) cross-sectional areas were measured manually. The presence of lesions was visually determined and the lesion volumes were calculated by the lesion growth algorithm as implemented in the Lesion Segmentation Toolbox. Right thalamic volume negatively correlated with Bain tremor severity score (ρ = - 0.65, p = 0.03). Left thalamic volume negatively correlated with general Bain tremor severity score (ρ = - 0.65, p = 0.03) and the Bain writing score (ρ = - 0.65, p = 0.03). Rig...Continue Reading

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Citations

Mar 26, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Frederique Mc BoonstraScott C Kolbe
Jul 18, 2018·Frontiers in Neurology·Frederique M C BoonstraScott C Kolbe
Sep 29, 2020·Frontiers in Neurology·Jingying WuLi Cao
Mar 4, 2019·The Cerebellum·Christophe HabasPierre Cabaraux
Jan 15, 2021·Scientific Reports·Richard McKinleyRoland Wiest
Nov 3, 2021·Biomedizinische Technik. Biomedical Engineering·Rene Peter BremmFrank Hertel
Nov 27, 2021·Seminars in Neurology·Andrea Lee, Harini Sarva

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

Freesurfer
OsiriX Lite
OsiriX
SPSS

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