Tremulous characteristics of the vacuous jaw movements induced by pilocarpine and ventrolateral striatal dopamine depletions

Pharmacology, Biochemistry, and Behavior
M FinnJohn D Salamone

Abstract

Vacuous jaw movements induced by the muscarinic agonist pilocarpine and striatal dopamine depletions were examined using a slow motion videotape system. With this procedure, rats were videotaped in a Plexiglas tube so that the profile of the head region could be seen. Vacuous jaw movements were analyzed by examining the tape at 1/6 normal speed. An observer recorded each jaw movement using a computer, and the computer program re-calculated the temporal characteristics of jaw movement responses back to normal speed. The interresponse time was recorded for each jaw movement, and each jaw movement interresponse time was assigned to a 50 ms wide time bin. Thus, the distribution of interresponse times could be used to analyze the temporal characteristics of jaw movement responses. In the first experiment, rats were administered saline vehicle, 1.0 mg/kg and 2.0 mg/kg pilocarpine. The rats were videotaped 10-15 min after injection, and the data were analyzed as described above. Pilocarpine induced very high levels of vacuous jaw movements, and the vast majority of all movements occurred in "bursts" with interresponse times of 1.0 s or less. Analysis of the interresponse time distributions showed that most of the jaw movements were wi...Continue Reading

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Citations

Sep 6, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·John D SalamoneMercè Correa
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·D L CarrieroJ D Salamone
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Oct 16, 2015·Pharmacology, Biochemistry, and Behavior·Samantha J PodurgielJohn D Salamone
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