Trending Towards Safer Breast Cancer Surgeries? Examining Acute Complication Rates from A 13-Year NSQIP Analysis

Cancers
Michael M JonczykAbhishek Chatterjee

Abstract

As breast cancer surgery continues to evolve, this study highlights the acute complication rates and predisposing risks following partial mastectomy (PM), mastectomy(M), mastectomy with muscular flap reconstruction (M + MF), mastectomy with implant reconstruction (M + I), and oncoplastic surgery (OPS). Data was collected from the American College of Surgeons NSQIP database (2005⁻2017). Complication rate and trend analyses were performed along with an assessment of odds ratios for predisposing risk factors using adjusted linear regression. 226,899 patients met the inclusion criteria. Complication rates have steadily increased in all mastectomy groups (p < 0.05). Cumulative complication rates between surgical categories were significantly different in each complication cluster (all p < 0.0001). Overall complication rates were: PM: 2.25%, OPS: 3.2%, M: 6.56%, M + MF: 13.04% and M + I: 5.68%. The most common predictive risk factors were mastectomy, increasing operative time, ASA class, BMI, smoking, recent weight loss, history of CHF, COPD and bleeding disorders (all p < 0.001). Patients who were non-diabetic, younger (age < 60) and treated as an outpatient all had protective OR for an acute complication (p < 0.0001). This study pr...Continue Reading

References

Mar 10, 2004·Annals of the Royal College of Surgeons of England·W J Sotheran, R M Rainsbury
Apr 19, 2006·Annals of Internal Medicine·Gerald W SmetanaUNKNOWN American College of Physicians
Feb 15, 2007·Allergy·J BousquetA Sheffer
Mar 26, 2008·Anesthesiology·Bradley G HammillAdrian F Hernandez
May 1, 2004·Seminars in Plastic Surgery·Grant W Carlson
Mar 17, 2011·Annals of Plastic Surgery·Eric I ChangChristopher A Crisera
Mar 23, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A ChakravortyF A Macneill
May 6, 2015·International Journal of Surgery·Nicholas J HackettJohn Y S Kim
Sep 28, 2015·Critical Care Clinics·Charles HobsonAzra Bihorac
Feb 3, 2016·Frontiers in Surgery·Daniel SchmaussYves Harder
Mar 16, 2016·Current Opinion in Anaesthesiology·Valérie Smit-Fun, Wolfgang F Buhre
Nov 22, 2016·Health Services Insights·Gilda Diaz-FuentesSindhaghatta Venkatram
Jan 26, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Mallika L MenduSushrut S Waikar
Mar 24, 2017·Breast Cancer : Targets and Therapy·Stuart A RobertsonRamsey I Cutress
Aug 24, 2017·Breast Cancer : Targets and Therapy·Esther Jennifer Campbell, Laszlo Romics
Aug 24, 2017·Plastic and Reconstructive Surgery. Global Open·Natalie D ChandRichard M Rainsbury
Mar 17, 2018·Breast Cancer Research and Treatment·Fernando A AngaritaTulin D Cil
Jun 26, 2018·The Journal of Surgical Research·Hang ChengPiet Hinoul
Aug 14, 2018·The Breast : Official Journal of the European Society of Mastology·Ammar AsbanAbhishek Chatterjee
Oct 27, 2018·Breast Cancer Research and Treatment·Michael M JonczykAbhishek Chatterjee

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Citations

Sep 5, 2019·Annals of Surgical Oncology·Edibaldo Silva, Mona Tan
Oct 2, 2020·The Annals of Otology, Rhinology, and Laryngology·Khodayar Goshtasbi, Sunil P Verma
May 30, 2020·Breast Cancer Research and Treatment·J S PalveM T Kääriäinen
Aug 1, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Gianluca VanniOreste Claudio Buonomo
Feb 2, 2021·Annals of Surgical Oncology·Julie A MargenthalerAbhishek Chatterjee
May 25, 2021·Journal of Surgical Oncology·Miguel A Gonzalez-WogeJuan E Bargallo-Rocha
Jun 29, 2021·Annals of Plastic Surgery·Ciara A BrownAlbert Losken

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