Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA: update from PROTEKT US Years 1-4

Annals of Clinical Microbiology and Antimicrobials
Stephen G JenkinsDavid J Farrell

Abstract

The increasing prevalence of resistance to established antibiotics among key bacterial respiratory tract pathogens, such as Streptococcus pneumoniae, is a major healthcare problem in the USA. The PROTEKT US study is a longitudinal surveillance study designed to monitor the susceptibility of key respiratory tract pathogens in the USA to a range of commonly used antimicrobials. Here, we assess the geographic and temporal trends in antibacterial resistance of S. pneumoniae isolates from patients with community-acquired respiratory tract infections collected between Year 1 (2000-2001) and Year 4 (2003-2004) of PROTEKT US. Antibacterial minimum inhibitory concentrations were determined centrally using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method; susceptibility was defined according to CLSI interpretive criteria. Macrolide resistance genotypes were determined by polymerase chain reaction. A total of 39,495 S. pneumoniae isolates were collected during 2000-2004. The percentage of isolates resistant to erythromycin, penicillin, levofloxacin, and telithromycin were 29.3%, 21.2%, 0.9%, and 0.02%, respectively, over the 4 years, with marked regional variability. The proportion of isolates exhibiting m...Continue Reading

References

Nov 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G V DoernR N Jones
Feb 13, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A CorsoA Tomasz
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V D ShortridgeR K Flamm
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C FogartyK Bush
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A KelleyM S Cohen
Jan 3, 2001·The New England Journal of Medicine·C G WhitneyUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Apr 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J HobanR N Jones
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M S NiedermanUNKNOWN American Thoracic Society
Aug 9, 2002·Clinical Pediatrics·Alejandro HobermanSandor Feldman
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R LonksAntone A Medeiros
Sep 13, 2002·Seminars in Respiratory Infections·Burke A Cunha
Jan 31, 2003·The Journal of Antimicrobial Chemotherapy·J J Canet, J Garau
Mar 5, 2003·The Journal of Antimicrobial Chemotherapy·D Van KerkhovenJ Verhaegen
Jul 25, 2003·Expert Opinion on Pharmacotherapy·Trevor DukeDavid G Fuller
Jan 17, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jack B AnonUNKNOWN Sinus And Allergy Health Partnership
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·David J Farrell, David Felmingham
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Stephanie J SchragUNKNOWN Active Bacterial Core Surveillance Team
Aug 4, 2004·International Journal of Antimicrobial Agents·Marek RzeszutekGeorge G Zhanel
Apr 23, 2005·Treatments in Respiratory Medicine·William R Bishai
Jun 21, 2005·Emerging Infectious Diseases·Keith P Klugman, John R Lonks
Jun 21, 2005·Emerging Infectious Diseases·David J FarrellKeith P Klugman
Jun 21, 2005·Emerging Infectious Diseases·Edward A BelongiaRichard E Besser
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary V DoernSusan Beekmann
Jul 19, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Daryl HobanDavid Felmingham
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lance R Peterson
Mar 15, 2006·The Journal of Antimicrobial Chemotherapy·Rosa del CampoUNKNOWN Spanish Pneumococcal Network (G3/103)

❮ Previous
Next ❯

Citations

Jun 20, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y H XiaoUNKNOWN MOH National Antimicrobial Resistance Investigation Net
Aug 27, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L SiiraA Virolainen
Apr 6, 2012·Current Infectious Disease Reports·Sadao Jinno, Michael R Jacobs
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mark S La Shell, Michael S Tankersley
Jul 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Belay AnagawChandrashekhar Unakal
Sep 3, 2010·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Marie KempfPhilippe Lanotte
Oct 20, 2009·The Journal of Antimicrobial Chemotherapy·Elia Gómez G de la PedrosaRafael Cantón
Apr 23, 2011·The Journal of Antimicrobial Chemotherapy·Takafumi SatoNaomasa Gotoh
Jun 17, 2011·International Journal of Clinical Practice·J A Bosso, R H Drew
Jul 15, 2009·Antimicrobial Agents and Chemotherapy·Colin S OsborneNeil S Ryder
Apr 14, 2010·Antimicrobial Agents and Chemotherapy·Mahesh N SamtaniPartha Nandy
Jan 18, 2012·Annals of Clinical Microbiology and Antimicrobials·Nedal TahaGhassan M Matar
Dec 3, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Konstantinos Z VardakasMatthew E Falagas
Sep 16, 2009·Emerging Infectious Diseases·Stephen G Jenkins, David J Farrell
Dec 21, 2013·International Journal of Circumpolar Health·Ryan W StevensMichael G Bruce
Mar 20, 2010·Journal of Global Infectious Diseases·Kiran ChawlaIndira Bairy
Feb 1, 2014·Applied Biochemistry and Biotechnology·Sandipan TalukdarParveen Kumar
Feb 19, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J Rodríguez de ItaJ Santos-Guzman
Jul 3, 2013·The Medical Clinics of North America·Samuel Y Ash, John V L Sheffield
Feb 13, 2013·Infectious Disease Clinics of North America·Veronique NussenblattSara Cosgrove
Jun 18, 2011·The Medical Clinics of North America·Jerry M ZuckermanBartholomew R Bono
Jun 19, 2010·International Journal of Antimicrobial Agents·Ronald N JonesHelio S Sader
Apr 23, 2010·International Journal of Antimicrobial Agents·M HoeniglA J Grisold
Apr 2, 2010·The American Journal of Medicine·Jack B Anon
Nov 17, 2009·Infectious Disease Clinics of North America·Jerry M ZuckermanBartholomew R Bono
Nov 1, 2008·Pediatric Annals·Natalie E Edmondson, Sanjay R Parikh
Mar 19, 2014·Pharmacology & Therapeutics·Michael J ParnhamRobin Vos
Sep 15, 2015·The Clinical Respiratory Journal·Bin CaoJohan Van Eldere
Jul 5, 2012·Journal of Chemotherapy·Saber YezliZiad A Memish
Mar 18, 2016·The Journal of Infectious Diseases·Kathrin GrissBernd Schmeck
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Aug 15, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Paulina A HawkinsLesley McGee
Jul 14, 2010·FEMS Microbiology Letters·Ji-Young LeeKwan Soo Ko
Feb 6, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J LiñaresA Fenoll
Oct 7, 2016·Frontiers in Cellular and Infection Microbiology·Max R Schroeder, David S Stephens

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

PROTEKT

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