Trends in Antihypertensive Medication Monotherapy and Combination Use Among US Adults, National Health and Nutrition Examination Survey 2005-2016.

Hypertension
Catherine G DeringtonAdam P Bress

Abstract

Blood pressure (BP) control rates among US adults taking antihypertensive medication have not increased over the past decade. Many adults require 2 or more classes of antihypertensive medication to achieve guideline-recommended BP goals, but the proportion of US adults taking antihypertensive medication monotherapy, versus combination therapy, has not been quantified using contemporary data. We analyzed data from 2005 to 2008, 2009 to 2012, and 2013 to 2016 National Health and Nutrition Examination Surveys to determine trends in monotherapy and combinations of antihypertensive medication classes among US adults age ≥20 years with hypertension taking antihypertensive medication (n=7837). The proportion of US adults taking antihypertensive medication with uncontrolled BP (ie, systolic BP ≥140 or diastolic BP ≥90 mm Hg) was 32.3%, 30.2%, and 31.0% in 2005 to 2008, 2009 to 2012, and 2013 to 2016, respectively (Ptrend=0.37). Between 2005 to 2008 and 2013 to 2016, there was no evidence of changes in the proportions of US adults taking antihypertensive monotherapy (39.5%-40.4%, Ptrend=0.67), dual-therapy (37.9%-38.3%, Ptrend=0.75), triple-therapy (17.6%-16.5%, Ptrend=0.36), or quadruple-therapy (4.4%-4.3%, Ptrend=0.93). Between 2005 t...Continue Reading

References

May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Nov 15, 2005·QJM : Monthly Journal of the Association of Physicians·B WilliamsS de Lusignan
Jan 5, 2006·Circulation·Qiuping GuVicki Burt
Dec 5, 2008·The New England Journal of Medicine·Kenneth JamersonUNKNOWN ACCOMPLISH Trial Investigators
Dec 19, 2008·The Journal of Clinical Hypertension·William C CushmanUNKNOWN ALLHAT Collaborative Research Group
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Mar 17, 2010·The New England Journal of Medicine·William C CushmanFaramarz Ismail-Beigi
May 27, 2010·JAMA : the Journal of the American Medical Association·Brent M EganR Neal Axon
Nov 12, 2010·Journal of Managed Care Pharmacy : JMCP·Boyang BianPatricia R Wigle
Mar 4, 2011·The Journal of Clinical Hypertension·Alan H GradmanUNKNOWN American Society of Hypertension Writing Group
Apr 19, 2013·International Journal of Audiology·C Spankovich, C G Le Prell
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Jan 1, 2015·Clinical Hypertension·Noah JarariLaxmi Teja Peela
May 23, 2017·American Journal of Hypertension·Shreya J Shah, Randall S Stafford
Apr 17, 2019·European Heart Journal·Bryan Williams, Giuseppe Mancia
Jul 20, 2019·Lancet·Ivor J BenjaminMichael Brainin

❮ Previous
Next ❯

Citations

Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Aug 28, 2020·Expert Review of Cardiovascular Therapy·Angel de la CruzJonathan N Bella
Apr 26, 2020·Journal of Human Hypertension·Catherine G DeringtonAdam P Bress
Oct 14, 2020·American Journal of Hypertension·Sascha DublinBruce M Psaty
Apr 3, 2021·Clinical Kidney Journal·Jordana B CohenMatthew A Sparks
Jan 5, 2021·Journal of Cardiovascular Pharmacology·Danyelle S MiottoSandra L Amaral
May 6, 2021·Amino Acids·Pawan Kumar RaghavDinesh Kumar
Oct 30, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Julie RouetteLaurent Azoulay

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.