Trends in birth weight and gestational age for infants born to HIV-infected, antiretroviral treatment-naive women in Malawi.

The Pediatric Infectious Disease Journal
T E TahaN Kumwenda

Abstract

We analyzed birth outcomes among infants of treatment-naive, HIV-infected women from a series of mother-to-child transmission of HIV studies in Blantyre, Malawi. Data from 6 prospective studies at 1 research site were analyzed. Mean birth weight (BW) and gestational age (GA), and frequency of low birth weight (LBW; <2500 g) and preterm (PT) birth (GA < 37 weeks) were estimated. We assessed risk factors for LBW and PT birth using mixed-effects logistic regression. Adjusted odds ratios (AOR) and 95% confidence intervals from earlier studies (1989-1994) and later studies (2000-2007) are presented separately. The analysis included 8874 HIV-exposed infants. Mean BW and GA ranged from 2793 to 3079 g, and from 37.8 to 39.0 weeks. Greater maternal age was consistently (during both the early and late periods) associated with lower odds of LBW and PT birth; AOR (95% confidence intervals) for both outcomes in the early and late periods, respectively, were 0.98 (0.96-1.00) and 0.97 (0.95-0.99). Female infant gender was consistently associated with higher odds of PT birth during both periods and with higher odds of LBW during the later period. During the early period, higher maternal education was associated with lower odds of LBW (AOR 0.67...Continue Reading

References

Sep 1, 1991·The Journal of Pediatrics·J L BallardR Lipp
Sep 1, 1996·Obstetrics and Gynecology·F D JohnstoneB A Hamilton
Jan 6, 1999·AIDS·G B Scott, R Tuomala
Dec 29, 2000·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·J R IckovicsM I Fernandez
Jun 14, 2002·The New England Journal of Medicine·Ruth E TuomalaMarc Bulterys
Jan 11, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·F MwanyumbaM Temmerman
Jul 14, 2004·JAMA : the Journal of the American Medical Association·Taha E TahaRobin L Broadhead
Nov 23, 2006·AIDS·Edgardo G SzyldUNKNOWN NISDI Perinatal Study Group
Jun 6, 2008·The New England Journal of Medicine·Newton I KumwendaTaha E Taha
Sep 5, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kathleen McDavid HarrisonXinjian Zhang
Mar 4, 2010·The Journal of Infectious Diseases·Kunjal PatelUNKNOWN P1025 team of the International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Apr 30, 2010·Bulletin of the World Health Organization·Stacy BeckPaul F A Van Look
Aug 18, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Maria ZolfoLutgarde Lynen
Dec 3, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kathleen M PowisRoger L Shapiro
Jan 1, 2011·Life·David L Abel

❮ Previous
Next ❯

Citations

Jul 13, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Abigail Norris TurnerJesse J Kwiek
Dec 24, 2019·International Health·Rekha Batura, Tim Colbourn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.