Trends in comorbidity, acuity, and maternal risk associated with preeclampsia across obstetric volume settings

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Whitney A BookerAlexander M Friedman

Abstract

The objective of this study was to characterize morbidity, acuity, and maternal risks associated with preeclampsia across hospitals with varying obstetric volumes. This retrospective cohort analysis used a large administrative data source, the Perspective database, to characterize the risk for preeclampsia from 2006 to 2015. Hospitals were classified as having either low (≤1000), moderate (1001-2000), or high (≥2000) delivery volume. The primary outcomes included preeclampsia, antihypertensive administration, comorbidity, and related severe maternal morbidity. Severe maternal morbidity was estimated using criteria from the Centers for Disease Control and Prevention. Comorbidity was estimated using an obstetric comorbidity index. Univariable comparisons were made with Chi-squared test. Adjusted log linear regression models were fit to assess factors associated with severe morbidity with risk ratios with 95% confidence intervals as the measures of effect. Population weights were applied to create national estimates. Of 36,985,729 deliveries included, 1,414,484 (3.8%) had a diagnosis of preeclampsia. Of these, 779,511 (2.1%) had mild, 171,109 (0.5%) superimposed, and 463,864 (1.3%) severe preeclampsia. The prevalence of mild, supe...Continue Reading

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Citations

Jul 5, 2021·Biological Chemistry·Yolanda CorreiaKeqing Wang
May 12, 2021·American Journal of Obstetrics and Gynecology·Alexander M Friedman, Mary E D'Alton
Aug 18, 2021·Current Opinion in Obstetrics & Gynecology·Alexander M Friedman
Dec 6, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·Timothy WenAlexander M Friedman

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