Trends in Deep Vein Thrombosis Prophylaxis and Deep Vein Thrombosis Rates After Total Hip and Knee Arthroplasty

The Journal of the American Academy of Orthopaedic Surgeons
Harpreet S BawaHue H Luu

Abstract

Patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) are at high risk of deep vein thrombosis (DVT) postoperatively, necessitating the use of prophylaxis medications. This investigation used a large claims database to evaluate trends in postoperative DVT prophylaxis and rates of DVT within 6 months after THA or TKA. Truven Health MarketScan Commercial Claims and Encounters and Medicare Supplemental and Coordination of Benefits databases were reviewed from 2004 to 2013 for patients who underwent THA or TKA. Data were collected on patient age, sex, Charlson Comorbidity Index, and hypercoagulability diagnoses. Postoperative medication claims were reviewed for prescribed aspirin, warfarin, enoxaparin, fondaparinux, rivaroxaban, and dabigatran. A total of 369,483 patients were included in the analysis, of which 239,949 patients had prescription medication claims. Warfarin was the most commonly prescribed anticoagulant. Patients with a hypercoagulable diagnosis had markedly more DVTs within 6 months after THA or TKA. More patients with a hypercoagulable diagnosis were treated with warfarin or lovenox than other types of anticoagulants. A multivariate regression analysis was performed, showing that patien...Continue Reading

References

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Citations

Jun 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Meng JiangXiaogang Li
Feb 20, 2021·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Zakk M BortonPeter W Howard
Nov 10, 2020·Journal of Orthopaedic Trauma·Graham J DeKeyserLucas S Marchand
Jun 17, 2021·BMC Musculoskeletal Disorders·Xinyan YuRende Ning
Jun 21, 2021·Knee Surgery & Related Research·Srihatach NgarmukosUNKNOWN Asia-Pacific (AP) Region Venous Thromboembolism (VTE) Consensus Group

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