Trends in Diagnostics, Surgical Treatment, and Prognostic Factors for Outcomes in Medullary Thyroid Carcinoma in Norway: A Nationwide Population-Based Study

European Thyroid Journal
Else Marie OpsahlTrine Bjøro

Abstract

Medullary thyroid carcinoma (MTC) is rare. Nationwide population-based studies are important to evaluate its clinical course. To describe all patients with MTC in Norway during 1994-2016 and compare time-related trends in diagnostics and surgical treatment, including prognostic factors for biochemical cure and disease-specific survival (DSS). This retrospective population-based cohort study includes data for 228 out of 237 patients (96%) with MTC; 201 patients were surgically treated. Patients were identified in the 4 regional centers treating MTC and by the Cancer Registry of Norway. Data were collected from patients' files. Trends were compared over 2 study periods. MTC accounted for 4.2% of thyroid carcinomas. During the study periods, the incidence increased from 0.18 to 0.25: 100,000 per year, preoperative diagnostics improved with increased use of calcitonin, ultrasound, and fine-needle cytology (p = 0.010, p < 0,001, and p = 0.001), patients were diagnosed at an earlier tumor stage (p = 0.004), and more patients were cured (p = 0.002). Via multivariate analysis of patients with metastatic lymph nodes, independent prognostic factors for cure were: a low ratio of metastatic and total number of dissected lymph nodes (p = 0....Continue Reading

References

Jul 1, 1993·Human Molecular Genetics·H Donis-KellerS A Wells
Feb 4, 2006·The Lancet Oncology·Gemma GattaUNKNOWN EUROCARE Working Group
Nov 24, 2006·Clinical Endocrinology·Jan Willem B de GrootThera P Links
Nov 28, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M R PelizzoD Rubello
Mar 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Kevin CheungJulie Ann Sosa
Jul 3, 2008·Annals of Surgical Oncology·Maya D LeggettSteve R Martinez
Mar 27, 2010·The Journal of Clinical Endocrinology and Metabolism·Andreas Machens, Henning Dralle
Oct 20, 2012·Current Opinion in Oncology·Henning Dralle, Andreas Machens
Dec 4, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Machens, H Dralle
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Jun 24, 2016·European Journal of Endocrinology·Andreas Machens, Henning Dralle
Jul 13, 2016·Thyroid : Official Journal of the American Thyroid Association·Else Marie OpsahlTrine Bjøro
Nov 15, 2017·World Journal of Surgery·Francesca TorresanMaurizio Iacobone
Feb 7, 2018·Thyroid : Official Journal of the American Thyroid Association·Dania HirschSimona Grozinsky-Glasberg

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Citations

Feb 29, 2020·The British Journal of Surgery·A MachensH Dralle
Apr 22, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bayan AlzumailiRonald A Ghossein
Nov 20, 2020·Endocrinology and Metabolism·Hwa Young AhnSin Gon Kim
May 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Friedhelm RaueKarin Frank-Raue
Jun 23, 2021·The British Journal of Surgery·D-J van BeekUNKNOWN EUROCRINE® Council
Jul 14, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Jürgen KratzschFriedhelm Raue
Sep 21, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Felix EckeltJuergen Kratzsch
Nov 4, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bin XuRonald A Ghossein

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