Trends in Haemophilus influenzae type b infections in adults in England and Wales: surveillance study

BMJ : British Medical Journal
J McVernonMary E Ramsay

Abstract

To describe invasive Haemophilus influenzae type b (Hib) infections in individuals aged 15 years or older in England and Wales between 1991 and 2003. Prospective, laboratory based surveillance of invasive Hib infections and cross sectional seroprevalence study. England and Wales. Cases were confirmed by isolation of H influenzae from a normally sterile site, or from a non-sterile site in cases with a diagnosis of epiglottitis. Excess serum samples collected from English 30-39 year olds as part of a national serosurvey were identified for the years 1990, 1994, 1997, 2000, and 2002. The number of invasive Hib infections from 1991 to 2003. Population immunity to H influenzae type b in English adults was also measured. After routine infant immunisation was introduced in October 1992, adult Hib infections decreased initially but then rose from a low in 1998 to reach prevaccine levels in 2003. An associated fall in median Hib antibody concentrations occurred, from 1.29 microg/ml (95% confidence interval 0.90 to 1.64) in 1991 to 0.70 microg/ml (0.57 to 0.89) in 1994 (P = 0.006), with no significant change observed thereafter. Although immunisation of infants resulted in an initial decline in Hib infections in adults, a resurgence in r...Continue Reading

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