Trends in health service use and potentially avoidable hospitalizations before Alzheimer's disease diagnosis: A matched, retrospective study of US Medicare beneficiaries

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Urvi DesaiJ Scott Andrews

Abstract

This study evaluates rates of all-cause emergency department visits, all-cause hospitalizations, potentially avoidable hospitalizations, and falls in 3 years preceding Alzheimer's disease (AD) diagnosis. Patients with AD and controls with no cognitive impairment were identified from the Medicare claims data. Patients were required to be aged ≥ 65 years and have continuous Medicare enrollment for ≥4 years before the index date (AD cohort: first AD diagnosis in 2012-2014; controls: randomly selected medical claim). Outcomes for each preindex year were compared among propensity score-matched cohorts. Each year, before index, patients with AD were more likely to have all-cause emergency department visits, all-cause hospitalizations, potentially avoidable hospitalizations, and falls (P < .05 for all comparisons) than matched controls (N = 19,679 pairs). Increasing absolute and relative risks over time were observed for all outcomes. The study findings highlight the growing burden of illness before AD diagnosis and emphasize the need for timely recognition and management of patients with AD.

References

Sep 10, 2002·Alzheimer Disease and Associated Disorders·Frank A Sloan, Donald H Taylor
Sep 7, 2006·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Edward T KelleyJulia Holmes
Feb 20, 2008·Journal of the International Neuropsychological Society : JINS·Ellen GroberClaudia Kawas
Mar 19, 2008·Annals of Internal Medicine·Brenda L PlassmanRobert B Wallace
Jul 18, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kenneth M LangaAllison B Rosen
Jun 18, 2010·Journal of the American Geriatrics Society·James L RudolphSharon K Inouye
Jan 12, 2012·JAMA : the Journal of the American Medical Association·Elizabeth A PhelanEric B Larson
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Pei-Jung LinPeter J Neumann
May 24, 2013·Applied Health Economics and Health Policy·David S GeldmacherVijay N Joish
Oct 15, 2013·Statistics in Medicine·Peter C Austin
Jun 19, 2014·Journal of General Internal Medicine·Dimitry S DavydowTheodore J Iwashyna
Jul 1, 2014·Health Services Research·Rebecca A HubbardJoshua J Fenton
Nov 2, 2014·BMC Medicine·Frances BunnCarol Brayne
Mar 17, 2017·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Christopher A TaylorLikang Xu
Nov 21, 2017·Journal of Alzheimer's Disease : JAD·Noam Y KirsonKristin Kahle-Wrobleski

❮ Previous
Next ❯

Citations

Aug 15, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Urvi DesaiJ Scott Andrews
Sep 19, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Brian DownerKenneth J Ottenbacher
Feb 11, 2021·Cadernos de saúde pública·Natan FeterAirton José Rombaldi
Oct 23, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Siddharth JainJeffrey H Silber
Mar 16, 2021·Journal of Parkinson's Disease·Julie M ChandlerNick Patel
Mar 18, 2021·AJR. American Journal of Roentgenology·Ritika ManikGelareh Sadigh
Apr 10, 2021·American Journal of Preventive Medicine·Jie ChenCharles F Reynolds

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.