Trends in hospital antibiotic prescribing after introduction of an antibiotic policy

The Journal of Antimicrobial Chemotherapy
I M Gould, B Jappy

Abstract

Trends in antibiotic prescribing in Grampian were monitored prospectively for seven years from 1986 using computerised ward stock lists and laboratory data relating to all in-patient and out-patient treatments in all Grampian hospitals serving a population of 500,000. The main outcome measures were the number of antibiotics available for routine and restricted uses, annual expenditure and defined daily doses (DDDs) of high expenditure antimicrobial agents. An antibiotic committee introduced a policy and formulary in the third year of the study which had only limited success in controlling prescribing. During the period of the study 30 new antibiotics were considered for inclusion in the hospital formulary, but only seven were incorporated, and all for restricted use only. Despite this, expenditure on antibiotics has more than doubled since 1986, two thirds of the increase being due to the use of new drugs. There was also an increased use of older antibiotics (DDDs increased by 33%), often for no clear reasons, and an overall increase of 46% in DDDs. Antibiotics have increased from 11.9-18.7% as a proportion of the drug budget. These findings highlight the current difficulty in controlling prescribing budgets, the increasing use...Continue Reading

Citations

Sep 26, 2002·Pharmacoepidemiology and Drug Safety·Roel FijnJacobus R B J Brouwers
Sep 22, 2005·European Journal of Clinical Pharmacology·Salih HoşoğluMustafa Kemal Celen
Feb 5, 2000·The Journal of Hospital Infection·V Krcmery, I M Gould
Jan 4, 2001·International Journal of Antimicrobial Agents·I C Gyssens
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Dec 1, 1998·Journal of Clinical Pharmacy and Therapeutics·S PaceyA Li Wan Po
Jun 6, 2000·The Journal of Antimicrobial Chemotherapy·I M Gould, B Jappy
Oct 22, 2004·Emerging Infectious Diseases·Dominique L MonnetIan M Gould
May 7, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L M Gould, UNKNOWN European Study Group on Antibiotic Policies
Dec 1, 1998·Journal of Clinical Pharmacy and Therapeutics·S Pacey, A Li Wan Po
Nov 20, 1998·The Journal of Infection·D Nathwani, P Davey
Feb 5, 2000·The Journal of Hospital Infection·I M Gould
Apr 9, 2002·Journal of Chemotherapy·I M Gould
Apr 3, 2015·International Journal of Clinical Pharmacy·Patricia Tarcea BizoAdina Popa
Sep 18, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A BorerF Schlaeffer
Apr 4, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I M GouldJ M van der Meer
Feb 8, 2000·The Journal of Antimicrobial Chemotherapy·R JanknegtJ W van der Meer
Apr 10, 2004·Pharmacoepidemiology and Drug Safety·Goran PalcevskiL Averchenkova
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Mar 20, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mirjana Stanić BenićVera Vlahović-Palčevski

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