Trends in Human Papillomavirus Vaccine Types 16 and 18 in Cervical Precancers, 2008-2014

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Nancy M McClungHPV-IMPACT Working Group

Abstract

The impact of human papillomavirus (HPV) vaccination has been observed in the United States through declining cervical precancer incidence in young women. To further evaluate vaccine impact, we described trends in HPV vaccine types 16/18 in cervical precancers, 2008-2014. We analyzed data from a 5-site, population-based surveillance system. Archived specimens from women age 18-39 years diagnosed with cervical intraepithelial neoplasia grades 2-3 or adenocarcinoma in situ (CIN2+) were tested for 37 HPV types. We described the proportion and estimated number of cases of CIN2+ by HPV-type groups over time. Trends in HPV16/18-positive CIN2+ were examined, overall and by vaccination status, age, histologic grade, and race/ethnicity, using Cochrane-Armitage tests. In 10,206 cases, the proportion and estimated number of cases of HPV16/18-positive CIN2+ declined from 52.7% (1,235 cases) in 2008 to 44.1% (819 cases) in 2014 (P < 0.001). Declining trends in the proportion of HPV16/18-positive CIN2+ were observed among vaccinated (55.2%-33.3%, P < 0.001) and unvaccinated (51.0%-47.3%, P = 0.03) women; ages 18-20 (48.7%-18.8%, P = 0.02), 21-24 (53.8%-44.0%, P < 0.001), 25-29 (56.9%-42.4%, P < 0.001), and 30-34 (49.8%-45.8%, P = 0.04) years...Continue Reading

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Citations

Apr 19, 2019·MMWR. Morbidity and Mortality Weekly Report·Nancy M McClungUNKNOWN HPV-IMPACT Working Group
Apr 14, 2019·International Journal of Cancer. Journal International Du Cancer·Angela A ClevelandUNKNOWN HPV-IMPACT Working Group
Apr 5, 2019·Current Opinion in Obstetrics & Gynecology·Brian J Morris
Jul 31, 2020·CA: a Cancer Journal for Clinicians·Elizabeth T H FonthamRobert A Smith
Apr 4, 2020·Journal of Lower Genital Tract Disease·Rebecca B PerkinsSusan T Vadaparampil
Oct 22, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jacqueline M MixCheryll C Thomas
Mar 9, 2021·Preventive Medicine·Ana Patricia OrtizGuillermo Tortolero-Luna
Jan 26, 2021·Sexually Transmitted Diseases·Harrell W ChessonLauri E Markowitz
Apr 3, 2021·Gynecologic Oncology·Luca GiannellaAndrea Ciavattini
Jun 13, 2021·Military Medicine·Collin A SitlerErica Hope
Sep 12, 2020·The American Journal of the Medical Sciences·Anahid M PahlawanianAgustin A Garcia
Sep 19, 2019·Pediatrics·Allison KempeMegan C Lindley

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