Trends in incidence of neonatal abstinence syndrome in Canada and associated healthcare resource utilization

Drug and Alcohol Dependence
Jacqueline FilteauKimberly Dow

Abstract

Neonatal abstinence syndrome (NAS) is a collection of symptoms that occurs primarily due to antenatal opioid exposure. National data on incidence, hospital resource utilization, and demographic features of NAS have not been previously described for Canada. Secondary analysis was performed with data from hospitals in all Canadian provinces and territories, excluding Quebec. Infants with NAS were identified by searching for ICD-10-CA code P96.1 in the Canadian Institute for Health Information's discharge abstract database. We examined incidence, hospital beds occupied per day, length of stay (fiscal 2003-2014), hospital costs, and demographic features (due to data availability, limited to fiscal 2010-2014). The incidence of NAS in Canada tripled between 2003 and 2014 (1.8-5.4 per 1000 live births), with an average annual increase of 0.33 cases per 1000 live births (95% CI 0.31, 0.34). Provincial incidence in 2014 ranged from 2.7 (Alberta) to 9.7 (New Brunswick) per 1000 live births. Between 2010 and 2014 total and mean per-patient costs rose from $15.7 to $26.9 million CAD and $14,629 to $17,367 CAD, respectively, with substantial inter-provincial variation in expenditure. Mean length of stay was 14.4 days in 2003 and 14.8 days i...Continue Reading

Citations

Aug 17, 2018·Journal of Developmental Origins of Health and Disease·C MillerA Black
Jun 5, 2020·Physical & Occupational Therapy in Pediatrics·Sandra FucileAnjali Patel
May 17, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Somayyeh ZakerabasaliShahabeddin Abhari
Feb 6, 2020·JAMA Pediatrics·Nathan M MoneyEric R Coon
Aug 5, 2020·Southern Medical Journal·Brook T AlemuHind A Beydoun
Oct 14, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Somayyeh ZakerabasaliAzadeh Sayarifard
Jun 5, 2020·Pediatrics·Lauren E KellyMartin Offringa

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