Trends in Long-Term Mortality and Morbidity in Patients with No Early Complications after Stroke and Transient Ischemic Attack

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Jodi D EdwardsRichard H Swartz

Abstract

Advances in acute management and secondary prevention have reduced mortality and early recurrent risk after stroke and transient ischemic attack (TIA). However, whether improved outcomes are sustained long term among those without early adverse complications is not clear. We describe trends in long-term mortality and morbidity in patients with ischemic stroke or TIA who are clinically stable at 90 days. This is a longitudinal cohort registry study (2003-2013) of patients presenting to stroke centers in Ontario, Canada, with a stroke or TIA, with no hospitalization, stroke, myocardial infarction (MI), institutionalization, or death within 90 days (N = 26,698). Primary outcomes were 1-, 3-, and 5-year age-adjusted composite rates of death, stroke or MI, and institutionalization, and secondary analyses evaluated outcomes individually. Trend tests were used to evaluate change over time. One-year adjusted composite rates decreased from 9.3% in 2003 to 7.4% in 2012 (trend test P = .02). Significant decreases in 3-year (P < .001) and 5-year (P = .002) composite rates were also observed. Rates of recurrent stroke decreased at 1 and 3 years (P < .01), but not 5 years (P = .21), whereas death rates declined across follow-up times. Conver...Continue Reading

Citations

Sep 13, 2018·American Journal of Speech-language Pathology·Jamie H AziosNancye Roussel
Nov 20, 2019·Journal of Clinical Laboratory Analysis·Jun WatanabeShizukiyo Ishikawa
Jul 3, 2019·International Journal of Molecular Sciences·Zhuqing JinPappachan E Kolattukudy
Feb 23, 2020·Stroke; a Journal of Cerebral Circulation·Reem WaziryM Kamran Ikram
Sep 23, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Ryan WangRichard H Swartz
Feb 25, 2021·BMJ Case Reports·Jing Wei Lim, Guat Cheng Ang

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