Trends in pediatric bacterial meningitis in Japan (2003-2004)

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
K SunakawaKeiko Hasegawa

Abstract

We surveyed the epidemiology of pediatric bacterial meningitis between January 2003 and December 2004 in Japan, with the following results: Bacterial meningitis cases numbered 233 (132 boys, 98 girls, and 3 unidentified), equivalent to 1.13-1.6 children of 1000 hospitalized in pediatrics per year. The age distribution for the infections was the highest under 1 year of age, decreasing with increasing age. Haemophilus influenzae was the most common pathogen, followed by Streptococcus pneumoniae, group B streptococcus, and Escherichia coli. The relationship between causactive pathogens and age distribution was as follows: group B. streptococcus and E. coli were major pathogens below 4 months of age and H. influenzae and S. pneumoniae were major pathogens above 4 months of age. Susceptibility tests at each facility demonstrated that 65.0% of H. influenzae isolates and 83.0% of S. pneumoniae isolates in 2004 were drug-resistant. Ampicillin and cephem antibiotics are currently effective against GBS, E. coli and Listeria so a combination of ampicillin and cephem antibiotics is used first line at many facilities for patients below 4 months of age. A combination of carbapenem which showed effective against PRSP and cephem which showed e...Continue Reading

Citations

Sep 30, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Fuminori SakaiKeisuke Sunakawa
Oct 27, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takao OzakiKeiji Funahashi
Apr 16, 2011·Epidemiology and Infection·A VyseM Soriano-Gabarro
Dec 16, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hiroshi Watanabe, Yoshiko Tsuchihashi

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