Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study

Acta Psychiatrica Scandinavica
A SekitaY Kiyohara

Abstract

To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population. Four cross-sectional examinations were conducted among residents of a Japanese community aged >or=65 in 1985, 1992, 1998 and 2005. The age- and sex-adjusted prevalence of all-cause dementia significantly increased with time (6.0% in 1985, 4.4% in 1992, 5.3% in 1998 and 8.3% in 2005; P for trend = 0.002). A similar trend was observed for AD (1.1%, 1.3%, 2.3% and 3.8% respectively; P for trend < 0.001), while the age- and sex-adjusted prevalence of VD and other/unclassified dementia showed J-shaped patterns (for VD: 2.3%, 1.5%, 1.5% and 2.5%, respectively, P for trend = 0.82; for other/unclassified dementia: 2.6%, 1.7%, 1.5% and 2.0%, P for trend = 0.26). The prevalence of AD was likely to increase with time from 1985 to 2005 among subjects aged 75 or older. The ratio of the prevalence of VD to that of AD decreased with time (2.1 in 1985, 1.2 in 1992, 0.7 in 1998 and 0.7 in 2005). Our findings suggest that the prevalence of all-cause dementia and AD significantly increased over the past two decades in the general Japanese population.

References

Sep 1, 1975·Archives of Neurology·V C HachinskiL Symon
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 1, 1986·Acta Psychiatrica Scandinavica·H ShibayamaH Kobayashi
Dec 22, 1999·Neurology·A OttM M Breteler
Jul 16, 2002·Archives of Neurology·Kenichi MeguroYasuyoshi Sekita
Mar 11, 2003·Dementia and Geriatric Cognitive Disorders·Li LiuJie-Lai Xia
Jul 16, 2003·Archives of Internal Medicine·Deborah GustafsonIngmar Skoog
May 19, 2004·Archives of Neurology·Zoe ArvanitakisDavid A Bennett
Mar 16, 2005·Archives of Neurology·Zhen-Xin ZhangHui Li
Dec 20, 2005·Lancet·Cleusa P FerriUNKNOWN Alzheimer's Disease International
Jun 15, 2006·Alzheimer Disease and Associated Disorders·Kathleen M HaydenUNKNOWN Cache County Investigators
Apr 14, 2007·Current Alzheimer Research·Rachel A WhitmerKristine Yaffe
Sep 7, 2007·Acta Psychiatrica Scandinavica·A LoboUNKNOWN ZARADEMP Workgroup
Nov 4, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·Y MatsuiY Kiyohara
Dec 5, 2008·Acta Psychiatrica Scandinavica·P SazA Lobo

❮ Previous
Next ❯

Citations

Oct 22, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yuriko KatsumataHiroko H Dodge
Aug 25, 2011·Alzheimer's Research & Therapy·Jeffrey CummingsKate Zhong
Apr 10, 2013·Clinical Interventions in Aging·Keiichi OnodaShuhei Yamaguchi
Aug 5, 2014·BioMed Research International·Liara RizziMatheus Roriz-Cruz
Jul 27, 2014·Maturitas·Yu-Tzu WuCarol Brayne
Jan 27, 2012·Rinshō shinkeigaku = Clinical neurology·Yutaka Kiyohara
Feb 10, 2016·European Journal of Epidemiology·Hiro KishimotoYutaka Kiyohara
Jun 12, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yaodong ZhangMinjie Zhang
Sep 6, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lewis H Kuller, Oscar L Lopez
Sep 22, 2015·Archives of Gerontology and Geriatrics·Nagato KuriyamaYoshiyuki Watanabe
Oct 24, 2012·International Journal of Alzheimer's Disease·Hiroko H DodgeJeffrey A Kaye
Apr 16, 2015·Annals of Nuclear Medicine·Michio SendaKerstin Heurling
Jul 31, 2016·Alzheimer's Research & Therapy·Martin PrinceYu-Tzu Wu
Jun 17, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kirsten M FiestDavid B Hogan
Jun 17, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kirsten M FiestNathalie Jetté
Jul 8, 2016·Diabetes Care·Naoki HirabayashiToshiharu Ninomiya
May 13, 2017·Nature Reviews. Neurology·Yu-Tzu WuCarol Brayne
Feb 9, 2017·Alzheimer Disease and Associated Disorders·Walter A Rocca
Dec 20, 2016·Journal of the American Geriatrics Society·Karine PérèsJean-François Dartigues
Nov 21, 2017·Journal of Alzheimer's Disease : JAD·Nagato KuriyamaYoshiyuki Watanabe
May 24, 2014·International Journal of Geriatric Psychiatry·Yu-Tzu WuCarol Brayne
May 11, 2011·Hypertension·Toshiharu NinomiyaYutaka Kiyohara
Jan 24, 2013·Metallomics : Integrated Biometal Science·Jie-Hua ChenThomas Walczyk
Jun 12, 2014·Journal of the American Geriatrics Society·Mio OzawaYutaka Kiyohara
Aug 8, 2014·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Janessa O CarvalhoHeather R Romero
Feb 24, 2017·Journal of Advanced Nursing·Akiko Watanabe, Sayuri Suwa
Oct 7, 2017·Journal of Alzheimer's Disease : JAD·James M NobleRichard Mayeux
Dec 24, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Leslie GrassetCatherine Helmer
Jun 18, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Hideomi HamasakiToru Iwaki
Oct 30, 2018·International Journal of Geriatric Psychiatry·Shohei Okamoto
Apr 21, 2017·Neurology·Tomoyuki OharaToshiharu Ninomiya
Mar 12, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Apr 10, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mozhu DingLaura Fratiglioni
Apr 10, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Keisuke YamasakiToshiharu Ninomiya
Jun 9, 2011·Journal of the American Geriatrics Society·Tomoyuki OharaYutaka Kiyohara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.