Trends in primary androgen depletion therapy for patients with localized and locally advanced prostate cancer: Japanese perspective

Cancer Science
Hideyuki Akaza

Abstract

It has been conventionally accepted that primary androgen depletion therapy (PADT) is effective only as a palliative treatment against localized prostate cancer (LPC) and locally advanced prostate cancer (LAPC), like its effect against advanced (metastatic) prostate cancer. In Japan, however, PADT has long been the treatment of choice for LPC and LAPC. The frequency of PADT being chosen to treat LPC and LAPC is also on the rise in clinical practice in the USA. Very little evidence to support this trend has so far been available. A study on the outcomes of endocrine therapy is currently being conducted in Japan by the Japanese Prostate Cancer Surveillance Group. Results of several domestic and overseas randomized trials have recently been published, and evidence for the efficacy of PADT in LPC and LAPC has been accumulating. The effectiveness of PADT in LAPC, in particular, is worthy of attention. There is a possibility that therapeutic strategies for LPC and LAPC may change dramatically in the near future.

References

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Citations

Jul 10, 2008·JAMA : the Journal of the American Medical Association·Grace L Lu-YaoSiu-Long Yao
Mar 23, 2012·Japanese Journal of Clinical Oncology·Norihito SogaYoshiki Sugimura
Dec 17, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Fernand LabrieClaes Ohlsson
May 13, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Hideyuki Akaza
Apr 22, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Mikio SugimotoYoshiyuki Kakehi
Apr 25, 2015·Clinical Genitourinary Cancer·Naohiro FujimotoIkko Tomisaki
Nov 2, 2016·Scandinavian Journal of Urology·Jacques PlanasJuan Morote
Dec 12, 2012·Yonsei Medical Journal·Dong Hoon LeeByung Ha Chung
Jan 19, 2011·Nature Reviews. Urology·Fernand Labrie
May 21, 2021·Cancer Science·Leandro BlasUNKNOWN Japan Study Group of Prostate Cancer (J-CaP)

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