Trends in the Management and Outcomes of Acute Pulmonary Embolism: Analysis From the RIETE Registry

Journal of the American College of Cardiology
David JiménezRIETE Investigators

Abstract

Despite advances in hospital management in recent years, it is not clear whether mortality after acute pulmonary embolism (PE) has decreased over time. This study describes the trends in the management and outcomes of acute symptomatic PE. We identified adults with acute PE enrolled in the registry between 2001 and 2013. We assessed temporal trends in length of hospital stay and use of pharmacological and interventional therapies. Using multivariable regression, we examined temporal trends in risk-adjusted rates of all-cause and PE-related death to 30 days after diagnosis. Among 23,858 patients with PE, mean length of stay decreased from 13.6 to 9.3 days over time (32% relative reduction, p < 0.001). For initial treatment, use of low-molecular-weight heparin increased from 77% to 84%, whereas the use of unfractionated heparin decreased from 22% to 8.4% (p < 0.001 for trend for all comparisons). Thrombolytic therapy use increased from 0.7% to 1.0% (p = 0.07 for trend) and surgical embolectomy use doubled from 0.3% to 0.6% (p < 0.01 for trend). Risk-adjusted rates of all-cause mortality decreased from 6.6% in the first period (2001 to 2005) to 4.9% in the last period (2010 to 2013) (p = 0.02 for trend). Rates of PE-related mortal...Continue Reading

Associated Clinical Trials

Apr 22, 2021·Richard N. Channick, Richard N. Channick

References

Jul 25, 1994·Archives of Internal Medicine·L A WittyV F Tapson
Sep 4, 1997·The New England Journal of Medicine·UNKNOWN Columbus InvestigatorsR Baildon
Oct 31, 2003·The New England Journal of Medicine·H R BüllerUNKNOWN Matisse Investigators
Apr 28, 2004·The American Journal of Cardiology·Paul D SteinRonald E Olson
Jun 3, 2010·JAMA : the Journal of the American Medical Association·Héctor BuenoHarlan M Krumholz
Aug 11, 2010·Archives of Internal Medicine·David JiménezUNKNOWN RIETE Investigators
Mar 16, 2012·Journal of Thrombosis and Haemostasis : JTH·A Riera-MestreUNKNOWN RIETE investigators
Jun 4, 2013·Thrombosis Research·Timothy P ShiraevR Louise Rushworth
Mar 1, 2014·Journal of the American College of Cardiology·Alfonso MurielUNKNOWN RIETE Investigators
Sep 17, 2014·JAMA : the Journal of the American Medical Association·Lana A CastellucciMarc Carrier

❮ Previous
Next ❯

Citations

Oct 28, 2016·Thrombosis and Haemostasis·Javier Trujillo-SantosUNKNOWN RIETE Investigators
Jan 25, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Carolyn L MulveyJason G Newman
Mar 23, 2017·Hospital Practice·Geoffrey BarnesUNKNOWN National PERT™ Consortium Research Committee
Dec 25, 2016·The American Journal of Medicine·Deisy BarriosUNKNOWN Registro Informatizado de la Enfermedad TromboEmbólica Investigators
Apr 16, 2017·Thrombosis Research·Philippe Girard, Guy Meyer
May 28, 2016·Journal of the American College of Cardiology·Behnood BikdeliNihar R Desai
Feb 28, 2017·Archivos de bronconeumología·Nuria Rodríguez-NúñezLuis Valdés
Mar 8, 2017·American Heart Journal·Deisy BarriosUNKNOWN PROTECT investigators
Feb 25, 2017·Journal of the American College of Cardiology·Valentin Fuster
Mar 7, 2017·Thrombosis Research·Farès MoustafaUNKNOWN RIETE Investigators
Nov 14, 2016·JACC. Cardiovascular Interventions·Meritxell MelladoUNKNOWN RIETE Investigators
Nov 29, 2016·Mayo Clinic Proceedings·Alana E SigmundEduardo Iturrate
Jul 5, 2017·Clinical Pharmacology and Therapeutics·Farès MoustafaUNKNOWN RIETE Investigators
Mar 16, 2018·Expert Review of Respiratory Medicine·Luke S Howard
Sep 28, 2017·Expert Opinion on Drug Discovery·Antonio Gómez-OutesMª Luisa Suárez-Gea
Feb 17, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thorsten KrammKaren M Olsson
Jul 19, 2018·Current Opinion in Pulmonary Medicine·Sake J van der WallF A Klok
Apr 20, 2018·American Journal of Respiratory and Critical Care Medicine·Parth M Rali, Gerard J Criner
Feb 19, 2017·Circulation. Cardiovascular Interventions·David M DudzinskiKenneth Rosenfield
Aug 30, 2018·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Carlos Andrés QuezadaDavid Jimenez
Oct 17, 2018·Current Opinion in Critical Care·Jason D Chodakowski, D Mark Courtney
Mar 7, 2019·The Cochrane Database of Systematic Reviews·Hugo Hb YooCathryn Broderick
May 5, 2018·The European Respiratory Journal·David JiménezUNKNOWN RIETE investigators
Mar 2, 2016·The European Respiratory Journal·David Jiménez, Roger D Yusen
Nov 6, 2018·The European Respiratory Journal·Alberto García-OrtegaMiguel Ángel Martínez-García
Nov 2, 2016·The European Respiratory Journal·Deisy BarriosUNKNOWN RIETE investigators
Mar 10, 2019·Journal of Thrombosis and Haemostasis : JTH·W Frank Peacock, Adam J Singer
Apr 6, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ling-Hsiang ChuangDavid Jimenez
May 19, 2019·European Heart Journal·Karsten KellerMareike Lankeit
Aug 14, 2019·JAMA : the Journal of the American Medical Association·Behnood BikdeliHarlan M Krumholz
Oct 1, 2019·Current Opinion in Critical Care·Usman A TahirDuane S Pinto
Oct 4, 2019·Angiology·Pablo Ruiz SadaUNKNOWN RIETE Investigators
Aug 24, 2019·Heart·Noura M DabbousehPaul Anthony Bergl
Aug 3, 2017·Cardiology in Review·Tanya DuttaWilbert S Aronow
May 6, 2019·Internal and Emergency Medicine·Meritxell MelladoUNKNOWN RIETE Investigators
May 8, 2020·Circulation·Peter K HenkeUNKNOWN American Heart Association Advocacy Coordinating Committee
Nov 2, 2019·Journal of Thrombosis and Thrombolysis·Donya MohebaliBrett J Carroll
Mar 11, 2017·Archivos de cardiología de México·Carlos Jerjes-SanchezAlicia Ramirez-Rivera
Feb 23, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Amanda J PiperVasileios Kouranos
Sep 2, 2018·Medicine·Brijesh PatelRaman Dusaj
Mar 8, 2019·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Marcelo Basso Gazzana, Igor Gorski Benedetto
Mar 7, 2019·American Journal of Therapeutics·Antoniu Octavian PetrişCălin Pop
Jun 18, 2020·World Journal of Cardiology·Anastasia Erythropoulou-KaltsidouKonstantinos Tziomalos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.