PMID: 11605516Oct 19, 2001Paper

Trends in the pharmaceutical research of ribonucleases and their therapeutic uses

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Y ZhangZ Su

Abstract

As one of the most popular model enzymes, the structure and evolution of ribonucleases (RNases) have been studied thoroughly. But until recently, scientists found out that RNases demonstrated a series of important biological functions, such as controlling blood vessel formation, killing tumor cells and inhibiting virus. Now immunotoxin, the antibody-toxin conjugate, becomes a research hot spot. RNases with cytotoxicity are the candidates for the toxin moiety of the immunotoxins. In this paper, the newly found cytotoxic functions of RNases are discussed in detail.

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